Advertisement
Research Article

Defining Childhood Severe Falciparum Malaria for Intervention Studies

  • Philip Bejon mail,

    To whom correspondence should be addressed. E-mail: pbejon@kilifi.kemri-wellcome.org

    Affiliations: Kenya Medical Research Institute (KEMRI)–Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

    X
  • James A Berkley,

    Affiliations: Kenya Medical Research Institute (KEMRI)–Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

    X
  • Tabitha Mwangi,

    Affiliation: Kenya Medical Research Institute (KEMRI)–Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya

    X
  • Edna Ogada,

    Affiliation: Kenya Medical Research Institute (KEMRI)–Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya

    X
  • Isaiah Mwangi,

    Affiliation: Kenya Medical Research Institute (KEMRI)–Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya

    X
  • Kathryn Maitland,

    Affiliations: Kenya Medical Research Institute (KEMRI)–Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya, Department of Paediatrics, Imperial College, London, United Kingdom, Wellcome Trust Centre for Clinical Tropical Medicine, Imperial College, London, United Kingdom

    X
  • Thomas Williams,

    Affiliations: Kenya Medical Research Institute (KEMRI)–Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya, Department of Paediatrics, The John Radcliffe Hospital University of Oxford, Oxford, United Kingdom

    X
  • J. Anthony G Scott,

    Affiliations: Kenya Medical Research Institute (KEMRI)–Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

    X
  • Mike English,

    Affiliations: Department of Paediatrics, The John Radcliffe Hospital University of Oxford, Oxford, United Kingdom, Nairobi KEMRI–Wellcome Trust Collaborative Research Programme, Kenyatta National Hospital, Nairobi, Kenya

    X
  • Brett S Lowe,

    Affiliations: Kenya Medical Research Institute (KEMRI)–Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

    X
  • Norbert Peshu,

    Affiliation: Kenya Medical Research Institute (KEMRI)–Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya

    X
  • Charles R. J. C Newton,

    Affiliations: Kenya Medical Research Institute (KEMRI)–Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya, Neurosciences Unit, Institute of Child Health, London, United Kingdom

    X
  • Kevin Marsh

    Affiliations: Kenya Medical Research Institute (KEMRI)–Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

    X
  • Published: August 21, 2007
  • DOI: 10.1371/journal.pmed.0040251

About the Authors

Philip Bejon, James A Berkley, Tabitha Mwangi, Edna Ogada, Isaiah Mwangi, Kathryn Maitland, Thomas Williams, J. Anthony G Scott, Brett S Lowe, Norbert Peshu, Charles R. J. C Newton, Kevin Marsh
Kenya Medical Research Institute (KEMRI)–Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya
Philip Bejon, James A Berkley, J. Anthony G Scott, Brett S Lowe, Kevin Marsh
Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom
Kathryn Maitland
Department of Paediatrics, Imperial College, London, United Kingdom
Kathryn Maitland
Wellcome Trust Centre for Clinical Tropical Medicine, Imperial College, London, United Kingdom
Thomas Williams, Mike English
Department of Paediatrics, The John Radcliffe Hospital University of Oxford, Oxford, United Kingdom
Mike English
Nairobi KEMRI–Wellcome Trust Collaborative Research Programme, Kenyatta National Hospital, Nairobi, Kenya
Charles R. J. C Newton
Neurosciences Unit, Institute of Child Health, London, United Kingdom

Corresponding Author

Email: pbejon@kilifi.kemri-wellcome.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The manuscript was written by P. Bejon, J. Berkley, C. Newton, and K. Marsh. Laboratory studies were conducted by B. Lowe. Clinical support was given by T. Mwangi, I. Mwangi, K. Maitland, J. Scott, M. English, N. Peshu, and C. Newton. Inpatient data were collected by K. Maitland, J. Scott, M. English, C. Newton, and K. Marsh. Outpatient data were collected by T. Mwangi, E. Ogada, and T. Williams. P. Bejon analysed the data. K. Maitland, J. Scott, and C. Newton contributed to interpretation of the results. All authors approved the final manuscript. P. Bejon had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.