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Research Article

Beta-Catenin Signaling Plays a Disparate Role in Different Phases of Fracture Repair: Implications for Therapy to Improve Bone Healing

  • Yan Chen,

    Affiliation: Program in Developmental and Stem Cell Biology, the Hospital for Sick Children, University of Toronto, Toronto, Canada

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  • Heather C Whetstone,

    Affiliation: Program in Developmental and Stem Cell Biology, the Hospital for Sick Children, University of Toronto, Toronto, Canada

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  • Alvin C Lin,

    Affiliation: Program in Developmental and Stem Cell Biology, the Hospital for Sick Children, University of Toronto, Toronto, Canada

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  • Puviindran Nadesan,

    Affiliation: Program in Developmental and Stem Cell Biology, the Hospital for Sick Children, University of Toronto, Toronto, Canada

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  • Qingxia Wei,

    Affiliation: Program in Developmental and Stem Cell Biology, the Hospital for Sick Children, University of Toronto, Toronto, Canada

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  • Raymond Poon,

    Affiliation: Program in Developmental and Stem Cell Biology, the Hospital for Sick Children, University of Toronto, Toronto, Canada

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  • Benjamin A Alman mail

    To whom correspondence should be addressed. E-mail: benjamin.alman@sickkids.ca

    Affiliations: Program in Developmental and Stem Cell Biology, the Hospital for Sick Children, University of Toronto, Toronto, Canada, Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Canada

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  • Published: July 31, 2007
  • DOI: 10.1371/journal.pmed.0040249

About the Authors

Yan Chen, Heather C Whetstone, Alvin C Lin, Puviindran Nadesan, Qingxia Wei, Raymond Poon, Benjamin A Alman
Program in Developmental and Stem Cell Biology, the Hospital for Sick Children, University of Toronto, Toronto, Canada
Benjamin A Alman
Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Canada

Corresponding Author

Email: benjamin.alman@sickkids.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

YC and BAA designed the study. YC, PN, QW, RP, and BAA analyzed the data. BAA enrolled patients. YC and BAA contributed to writing the paper. YC, HCW, and ACL collected data or performed experiments for this study. ACL provided mice expressing osteoblast-specific β-catenin null alleles. PN helped in transgenic mice work. QW provided the Ad-Cre virus that was used for this study.