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Research Article

Canine and Human Visual Cortex Intact and Responsive Despite Early Retinal Blindness from RPE65 Mutation

  • Geoffrey K Aguirre mail,

    To whom correspondence should be addressed. E-mail: aguirreg@mail.med.upenn.edu

    Affiliation: Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • András M Komáromy,

    Affiliation: Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Artur V Cideciyan,

    Affiliation: Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • David H Brainard,

    Affiliation: Department of Psychology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Tomas S Aleman,

    Affiliation: Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Alejandro J Roman,

    Affiliation: Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Brian B Avants,

    Affiliation: Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • James C Gee,

    Affiliation: Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Marc Korczykowski,

    Affiliation: Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • William W Hauswirth,

    Affiliation: Department of Ophthalmology, University of Florida, Gainesville, Florida

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  • Gregory M Acland,

    Affiliation: Baker Institute, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America

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  • Gustavo D Aguirre,

    Affiliation: Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Geoffrey K Aguirre

    Affiliation: Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Published: June 26, 2007
  • DOI: 10.1371/journal.pmed.0040230

About the Authors

Geoffrey K Aguirre, Marc Korczykowski
Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
András M Komáromy, Gustavo D Aguirre
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Artur V Cideciyan, Tomas S Aleman, Alejandro J Roman, Geoffrey K Aguirre
Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
David H Brainard
Department of Psychology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Brian B Avants, James C Gee
Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
William W Hauswirth
Department of Ophthalmology, University of Florida, Gainesville, Florida
Gregory M Acland
Baker Institute, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America

Corresponding Author

Email: aguirreg@mail.med.upenn.edu

Competing Interests

WWH and the University of Florida have a financial interest in the company AGTC, which might commercialize some of the technology described in this paper. A conflict of interest monitoring plan is in place at the University of Florida.

Author Contributions

GKA, AMK, AVC, DHB, TSA, WWH, GMA, GDA, and SGJ contributed to the design of the study. GKA, AMK, AVC, TSA, AJR, MK, WWH, GMA, GDA, and SGJ collected data or performed experiments for this study. GKA, AMK, AVC, DHB, TSA, AJR, BBA, JCG, MK, WWH, GMA, GDA, and SGJ contributed to data analysis or development of methodology. SGJ enrolled patients. GKA, AMK, AVC, DHB, TSA, AJR, MK, WWH, GMA, GDA and SGJ contributed to writing the paper.