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Research Article

Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target

  • Angela N Kuntz,

    Affiliation: Department of Biological Sciences, Illinois State University, Normal, Illinois, United States of America

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  • Elisabeth Davioud-Charvet,

    Affiliations: Biochemie-Zentrum der Universität Heidelberg, Heidelberg, Germany, Centre National de la Recherche Scientifique (CNRS), Paris, France

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  • Ahmed A Sayed,

    Affiliation: Department of Biological Sciences, Illinois State University, Normal, Illinois, United States of America

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  • Lindsay L Califf,

    Affiliation: Department of Biological Sciences, Illinois State University, Normal, Illinois, United States of America

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  • Jean Dessolin,

    Affiliations: Biochemie-Zentrum der Universität Heidelberg, Heidelberg, Germany, Institut Européen de Chimie et Biologie, CNRS UMR 5144, Bordeaux University, Pessac Cedex, France

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  • Elias S. J Arnér,

    Affiliation: Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

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  • David L Williams mail

    To whom correspondence should be addressed. E-mail: dlwilli@ilstu.edu

    Affiliation: Department of Biological Sciences, Illinois State University, Normal, Illinois, United States of America

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  • Published: June 19, 2007
  • DOI: 10.1371/journal.pmed.0040206

About the Authors

Angela N Kuntz, Ahmed A Sayed, Lindsay L Califf, David L Williams
Department of Biological Sciences, Illinois State University, Normal, Illinois, United States of America
Elisabeth Davioud-Charvet, Jean Dessolin
Biochemie-Zentrum der Universität Heidelberg, Heidelberg, Germany
Elisabeth Davioud-Charvet
Centre National de la Recherche Scientifique (CNRS), Paris, France
Jean Dessolin
Institut Européen de Chimie et Biologie, CNRS UMR 5144, Bordeaux University, Pessac Cedex, France
Elias S. J Arnér
Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

Corresponding Author

Email: dlwilli@ilstu.edu

Competing Interests

All authors have read and approved of the contents of the manuscript and none of the authors have competing financial interests. There is no significant overlap between the submitted manuscript and any other papers from the same authors under consideration or in press elsewhere.

Author Contributions

ANK, EDC, AAS, ESJA, and DLW designed the study. ANK, EDC, AAS, and LLC collected data or did experiments for the study. ANK performed the experiments involving recombinant protein expression, biochemical analysis, inhibition assays, and in vitro worm assays, and helped with in vivo experiments. AAS performed the experiments involving RNA interference, cytotoxicity assays, and helped with in vivo experiments. LLC participated in experimental drug studies to test the effects of auranofin on mice infected with S. mansoni and interpreted the results. JD synthesized some of the compounds described herein. ANK, EDC, AAS, LLC, ESJA, and DLW analyzed the data. ANK, EDC, ESJA, and DLW contributed to writing the paper. JD proofread the manuscript prior to submission.