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Research Article

Commercial Serological Antibody Detection Tests for the Diagnosis of Pulmonary Tuberculosis: A Systematic Review

  • Karen R Steingart,

    Affiliations: Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, California, United States of America, Francis J. Curry National Tuberculosis Center, San Francisco, California, United States of America

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  • Megan Henry,

    Affiliation: County of Sacramento Department of Health and Human Services, Sacramento, California, United States of America

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  • Suman Laal,

    Affiliations: Department of Pathology, New York, New York, United States of America, Department of Microbiology, New York University School of Medicine, New York, New York, United States of America, Veterans Affairs Medical Center, New York, United States of America

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  • Philip C Hopewell,

    Affiliations: Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, California, United States of America, Francis J. Curry National Tuberculosis Center, San Francisco, California, United States of America

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  • Andrew Ramsay,

    Affiliation: UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, World Health Organization, Geneva, Switzerland

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  • Dick Menzies,

    Affiliations: Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Canada, Respiratory Epidemiology and Clinical Research Unit, Montréal Chest Institute, Montréal, Canada

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  • Jane Cunningham,

    Affiliation: UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, World Health Organization, Geneva, Switzerland

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  • Karin Weldingh,

    Affiliation: Statens Serum Institut, Department of Infectious Disease Immunology, Copenhagen, Denmark

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  • Madhukar Pai mail

    To whom correspondence should be addressed. E-mail: madhukar.pai@mcgill.ca

    Affiliations: Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Canada, Respiratory Epidemiology and Clinical Research Unit, Montréal Chest Institute, Montréal, Canada

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  • Published: June 12, 2007
  • DOI: 10.1371/journal.pmed.0040202

About the Authors

Karen R Steingart, Philip C Hopewell
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, California, United States of America
Karen R Steingart, Philip C Hopewell
Francis J. Curry National Tuberculosis Center, San Francisco, California, United States of America
Megan Henry
County of Sacramento Department of Health and Human Services, Sacramento, California, United States of America
Suman Laal
Department of Pathology, New York, New York, United States of America
Suman Laal
Department of Microbiology, New York University School of Medicine, New York, New York, United States of America
Suman Laal
Veterans Affairs Medical Center, New York, United States of America
Andrew Ramsay, Jane Cunningham
UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, World Health Organization, Geneva, Switzerland
Dick Menzies, Madhukar Pai
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Canada
Dick Menzies, Madhukar Pai
Respiratory Epidemiology and Clinical Research Unit, Montréal Chest Institute, Montréal, Canada
Karin Weldingh
Statens Serum Institut, Department of Infectious Disease Immunology, Copenhagen, Denmark

Corresponding Author

Email: madhukar.pai@mcgill.ca

Competing Interests

KW is co-inventor on a number of patents relating to mycobacterial antigens which may be used for serological assays. All rights have been assigned to Statens Serum Institut.

Author Contributions

KRS, SL, PCH, AR, DM, JC, KW, and MP conceived and designed the study. KRS and MH collected and analyzed the data. KRS, MH, SL, AR, DM, KW, and MP interpreted the data. KRS, SL, and MP drafted the manuscript. KRS, SL, PCH, AR, DM, JC, KW, and MP performed critical revision of the manuscript.