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Research Article

Vascular Endothelial Growth Factor Mediates Intracrine Survival in Human Breast Carcinoma Cells through Internally Expressed VEGFR1/FLT1

  • Tae-Hee Lee,

    Affiliation: Division of Experimental Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

    ¤ Current address: CHA Stem Cell Institute, College of Medicine, Pochon Cha University, Seoul, Republic of Korea

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  • Seyha Seng,

    Affiliation: Division of Experimental Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Masayuki Sekine,

    Affiliation: Division of Experimental Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Cimona Hinton,

    Affiliation: Division of Experimental Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Yigong Fu,

    Affiliation: Division of Experimental Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Hava Karsenty Avraham,

    Affiliation: Division of Experimental Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Shalom Avraham mail

    To whom correspondence should be addressed. E-mail: savraham@bidmc.harvard.edu

    Affiliation: Division of Experimental Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: June 05, 2007
  • DOI: 10.1371/journal.pmed.0040186

About the Authors

Tae-Hee Lee, Seyha Seng, Masayuki Sekine, Cimona Hinton, Yigong Fu, Hava Karsenty Avraham, Shalom Avraham
Division of Experimental Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: savraham@bidmc.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

THL, CH, YF, HKA, and SA designed the study. THL, SS, CH, YF, HKA, and SA analyzed the data. All authors contributed to writing the paper. SS, MS, CH, and YF collected data or performed experiments for the study. THL performed experiments for Figures 1–6 and 10, except for Figure 4C.