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Research Article

HIV Impairs Opsonic Phagocytic Clearance of Pregnancy-Associated Malaria Parasites

  • Jessica Keen,

    Affiliation: Faculty of Medicine, University of Toronto, Toronto, Canada

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  • Lena Serghides,

    Affiliations: Faculty of Medicine, University of Toronto, Toronto, Canada, McLaughlin-Rotman Centre, McLaughlin Center for Molecular Medicine, University of Toronto, Toronto, Canada, University Health Network, Toronto, Canada

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  • Kodjo Ayi,

    Affiliation: Faculty of Medicine, University of Toronto, Toronto, Canada

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  • Samir N Patel,

    Affiliation: Faculty of Medicine, University of Toronto, Toronto, Canada

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  • John Ayisi,

    Affiliation: Center for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya

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  • Anne van Eijk,

    Affiliation: Center for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya

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  • Richard Steketee,

    Affiliation: Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Venkatachalam Udhayakumar,

    Affiliation: Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Kevin C Kain mail

    To whom correspondence should be addressed. E-mail: kevin.kain@uhn.on.ca

    Affiliations: Faculty of Medicine, University of Toronto, Toronto, Canada, McLaughlin-Rotman Centre, McLaughlin Center for Molecular Medicine, University of Toronto, Toronto, Canada, University Health Network, Toronto, Canada

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  • Published: May 29, 2007
  • DOI: 10.1371/journal.pmed.0040181

About the Authors

Jessica Keen, Lena Serghides, Kodjo Ayi, Samir N Patel, Kevin C Kain
Faculty of Medicine, University of Toronto, Toronto, Canada
Lena Serghides, Kevin C Kain
McLaughlin-Rotman Centre, McLaughlin Center for Molecular Medicine, University of Toronto, Toronto, Canada
Lena Serghides, Kevin C Kain
University Health Network, Toronto, Canada
John Ayisi, Anne van Eijk
Center for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya
Richard Steketee, Venkatachalam Udhayakumar
Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

Corresponding Author

Email: kevin.kain@uhn.on.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KCK designed the study with JK, LS, KA, SNP, JA, AvE, RS, and VU. JA, AvE, RS, and VU organized collection of clinical samples and clinical data. JK, LS, KA, and SNP conducted the experiments. JK, LS, and KCK analysed the data with input from all authors. JK wrote the manuscript with input from all the authors.