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Research Article

Prophylactic and Therapeutic Efficacy of Human Monoclonal Antibodies against H5N1 Influenza

  • Cameron P Simmons equal contributor,

    equal contributor Contributed equally to this work with: Cameron P Simmons, Nadia L Bernasconi, Amorsolo L Suguitan Jr., Kimberly Mills

    Affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam

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  • Nadia L Bernasconi equal contributor,

    equal contributor Contributed equally to this work with: Cameron P Simmons, Nadia L Bernasconi, Amorsolo L Suguitan Jr., Kimberly Mills

    Affiliation: Institute for Research in Biomedicine, Bellinzona, Switzerland

    X
  • Amorsolo L Suguitan Jr. equal contributor,

    equal contributor Contributed equally to this work with: Cameron P Simmons, Nadia L Bernasconi, Amorsolo L Suguitan Jr., Kimberly Mills

    Affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Kimberly Mills equal contributor,

    equal contributor Contributed equally to this work with: Cameron P Simmons, Nadia L Bernasconi, Amorsolo L Suguitan Jr., Kimberly Mills

    Affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Jerrold M Ward,

    Affiliation: Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Nguyen Van Vinh Chau,

    Affiliation: Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam

    X
  • Tran Tinh Hien,

    Affiliation: Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam

    X
  • Federica Sallusto,

    Affiliation: Institute for Research in Biomedicine, Bellinzona, Switzerland

    X
  • Do Quang Ha,

    Affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam

    X
  • Jeremy Farrar,

    Affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam

    X
  • Menno D de Jong,

    Affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam

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  • Antonio Lanzavecchia mail,

    To whom correspondence should be addressed. E-mail: lanzavecchia@irb.unisi.ch (AL); ksubbarao@niaid.nih.gov (KS)

    Affiliation: Institute for Research in Biomedicine, Bellinzona, Switzerland

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  • Kanta Subbarao mail

    To whom correspondence should be addressed. E-mail: lanzavecchia@irb.unisi.ch (AL); ksubbarao@niaid.nih.gov (KS)

    Affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: May 29, 2007
  • DOI: 10.1371/journal.pmed.0040178

About the Authors

Cameron P Simmons, Do Quang Ha, Jeremy Farrar, Menno D de Jong
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
Nadia L Bernasconi, Federica Sallusto, Antonio Lanzavecchia
Institute for Research in Biomedicine, Bellinzona, Switzerland
Amorsolo L Suguitan Jr., Kimberly Mills, Kanta Subbarao
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Jerrold M Ward
Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Nguyen Van Vinh Chau, Tran Tinh Hien
Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam

Corresponding Authors

Competing Interests

AL is named on a patent relating to the generation and use of human monoclonal antibodies. All other authors have no conflict of interest.

Author Contributions

CPS, NVVC, TTH, JF, and MDdJ diagnosed and recruited the patients. NB, FS and AL generated the antibodies. CS, AS, KM, MDdJ, DQH, and KS tested the antibodies in vitro and in vivo. JMW performed histopathology. CS, NB, AS, AL and KS analyzed the data and wrote the manuscript, with input from all.