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Research Article

Understanding the Slow Depletion of Memory CD4+ T Cells in HIV Infection

  • Andrew Yates mail,

    To whom correspondence should be addressed. E-mail: ayates2@emory.edu

    Affiliations: Department of Biology, Emory University, Atlanta, Georgia, United States of America, Centre for Mathematics and Physics in the Life Sciences and Experimental Biology, University College London, London, United Kingdom

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  • Jaroslav Stark,

    Affiliations: Department of Mathematics, Imperial College, London, United Kingdom, Centre for Integrative Systems Biology at Imperial College, Imperial College London, United Kingdom

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  • Nigel Klein,

    Affiliation: Immunobiology Unit, Institute of Child Health, London, United Kingdom

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  • Rustom Antia,

    Affiliation: Department of Biology, Emory University, Atlanta, Georgia, United States of America

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  • Robin Callard

    Affiliations: Centre for Mathematics and Physics in the Life Sciences and Experimental Biology, University College London, London, United Kingdom, Immunobiology Unit, Institute of Child Health, London, United Kingdom

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  • Published: May 22, 2007
  • DOI: 10.1371/journal.pmed.0040177

About the Authors

Andrew Yates, Rustom Antia
Department of Biology, Emory University, Atlanta, Georgia, United States of America
Andrew Yates, Robin Callard
Centre for Mathematics and Physics in the Life Sciences and Experimental Biology, University College London, London, United Kingdom
Jaroslav Stark
Department of Mathematics, Imperial College, London, United Kingdom
Jaroslav Stark
Centre for Integrative Systems Biology at Imperial College, Imperial College London, United Kingdom
Nigel Klein, Robin Callard
Immunobiology Unit, Institute of Child Health, London, United Kingdom

Corresponding Author

Email: ayates2@emory.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AY, NK, and RC designed the study. AY wrote the paper and performed the modelling. NK, RC, RA and JS contributed to writing the paper and to the development of the models.