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Research Article

Down-Regulation of the Interferon Signaling Pathway in T Lymphocytes from Patients with Metastatic Melanoma

  • Rebecca J Critchley-Thorne,

    Affiliation: Division of Hematology, Department of Medicine, Stanford University, Stanford, California, United States of America

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  • Ning Yan,

    Affiliations: Division of Hematology, Department of Medicine, Stanford University, Stanford, California, United States of America, Department of Statistics, Stanford University, Stanford, California, United States of America

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  • Serban Nacu,

    Affiliation: Department of Statistics, Stanford University, Stanford, California, United States of America

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  • Jeffrey Weber,

    Affiliation: Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

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  • Susan P Holmes,

    Affiliation: Department of Statistics, Stanford University, Stanford, California, United States of America

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  • Peter P Lee mail

    To whom correspondence should be addressed. E-mail: ppl@stanford.edu

    Affiliation: Division of Hematology, Department of Medicine, Stanford University, Stanford, California, United States of America

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  • Published: May 08, 2007
  • DOI: 10.1371/journal.pmed.0040176

About the Authors

Rebecca J Critchley-Thorne, Ning Yan, Peter P Lee
Division of Hematology, Department of Medicine, Stanford University, Stanford, California, United States of America
Ning Yan, Serban Nacu, Susan P Holmes
Department of Statistics, Stanford University, Stanford, California, United States of America
Jeffrey Weber
Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

Corresponding Author

Email: ppl@stanford.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

RJCT, SPH, and PPL designed the study. RJCT performed the laboratory experiments. JW enrolled patients and collected PBMCs from patients. RJCT, NY, and SPH analyzed data. NY, SN, and SPH analyzed gene expression data and performed statistical analysis for the study. RJCT, NY, and PPL contributed to writing the manuscript.