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Research Article

Vaccinating to Protect a Vulnerable Subpopulation

  • Jonathan Dushoff mail,

    To whom correspondence should be addressed. E-mail: dushoff@eno.princeton.edu

    Affiliations: Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America, Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Joshua B Plotkin,

    Affiliation: Department of Biology, University of Pennsylvania, United States of America

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  • Cecile Viboud,

    Affiliation: Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Lone Simonsen,

    Affiliation: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda Maryland, United States of America

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  • Mark Miller,

    Affiliation: Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Mark Loeb,

    Affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada

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  • David J. D Earn

    Affiliation: Department of Mathematics and Statistics, McMaster University, Hamilton, Ontario, Canada

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  • Published: May 22, 2007
  • DOI: 10.1371/journal.pmed.0040174

About the Authors

Jonathan Dushoff
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America
Jonathan Dushoff, Cecile Viboud, Mark Miller
Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America
Joshua B Plotkin
Department of Biology, University of Pennsylvania, United States of America
Lone Simonsen
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda Maryland, United States of America
Mark Loeb
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
David J. D Earn
Department of Mathematics and Statistics, McMaster University, Hamilton, Ontario, Canada

Corresponding Author

Email: dushoff@eno.princeton.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

All authors discussed framing and interpretation, and contributed to writing the paper. JD conceived the study and implemented the model. DJDE and JBP helped develop the model and the techniques used to explore parameter space. LS and CV helped guide the exploration of parameter space, including vaccination scenarios and sensitivity analyses. MM and ML contributed to evaluating and clarifying the assumptions and interpretations of the model.