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Research Article

Traditional Nonsteroidal Anti-Inflammatory Drugs and Postmenopausal Hormone Therapy: A Drug–Drug Interaction?

  • Luis Alberto García Rodríguez,

    Affiliation: Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain

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  • Karine Egan,

    Affiliation: The Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Garret A FitzGerald mail

    To whom correspondence should be addressed. E-mail: garret@spirit.gcrc.upenn.edu

    Affiliation: The Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Published: May 22, 2007
  • DOI: 10.1371/journal.pmed.0040157

About the Authors

Luis Alberto García Rodríguez
Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain
Karine Egan, Garret A FitzGerald
The Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: garret@spirit.gcrc.upenn.edu

Competing Interests

The original dataset, which was the basis of a previous paper (Garcia Rodriguez LA, Varas-Lorenzo C, Maguire A, Gonzalez-Perez A (2004) Nonsteroidal antiinflammatory drugs and the risk of myocardial infarction in the general population. Circulation 109: 3000–3006), was performed thanks to a research grant from Pharmacia (now Pfizer). KE has nothing to declare. LAGR receives unrestricted research grants from Pfizer and Novartis, both of which manufacture drugs that target COXs. GAF receives financial support for investigator-initiated research from Bayer, Merck, and Boehringer Ingelheim, all of which manufacture drugs that target COXs. GAF has also served as a consultant for Astra Zeneca, Bayer, Biolipox, Boehringer Ingelheim, deCode, Merck, GlaxoSmithKline, Genome Institute of the Novartis Foundation, Lilly, Novartis, NicOx and Via Pharmaceuticals.

Author Contributions

LAGR provided analysis of the database, interpretation of findings, and preparation of manuscript. KE provided concept of study. GAF provided concept of study, interpretation of findings, and preparation of manuscript.