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Research Article

Signature-Based Small Molecule Screening Identifies Cytosine Arabinoside as an EWS/FLI Modulator in Ewing Sarcoma

  • Kimberly Stegmaier,

    Affiliations: Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America, The Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Jenny S Wong,

    Affiliations: Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Kenneth N Ross,

    Affiliation: The Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Kwan T Chow,

    Affiliation: Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America

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  • David Peck,

    Affiliation: The Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Renee D Wright,

    Affiliation: Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Stephen L Lessnick,

    Affiliation: The Center for Children, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America

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  • Andrew L Kung,

    Affiliation: Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Todd R Golub mail

    To whom correspondence should be addressed. E-mail: golub@broad.mit.edu

    Affiliations: Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America, The Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: April 10, 2007
  • DOI: 10.1371/journal.pmed.0040122

About the Authors

Kimberly Stegmaier, Jenny S Wong, Kwan T Chow, Renee D Wright, Andrew L Kung, Todd R Golub
Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America
Kimberly Stegmaier, Kenneth N Ross, David Peck, Todd R Golub
The Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Jenny S Wong, Todd R Golub
Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America
Stephen L Lessnick
The Center for Children, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America

Corresponding Author

Email: golub@broad.mit.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KS and TRG designed the study and wrote the manuscript. KS, JSW, and KTC performed the research and analyzed data. KNR performed the computational analyses. RDW and ALK performed and analyzed the xenograft experiments. SLL developed the EWS/FLI directed RNAi system. DP contributed to technical development of the GE-HTS platform.