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Research Article

Rotavirus Antigenemia in Children Is Associated with Viremia

  • Sarah E Blutt,

    Affiliations: Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America, Michael E. Debakey Veterans Affairs Medical Center, Houston, Texas, United States of America

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  • David O Matson,

    Affiliation: Center for Pediatric Research, Norfolk, Virginia, United States of America

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  • Sue E Crawford,

    Affiliation: Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Mary Allen Staat,

    Affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

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  • Parvin Azimi,

    Affiliation: Children's Hospital of Oakland, Oakland, California, United States of America

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  • Berkeley L Bennett,

    Affiliation: Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Pedro A Piedra,

    Affiliation: Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Margaret E Conner mail

    To whom correspondence should be addressed. E-mail: mconner@bcm.tmc.edu

    Affiliations: Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America, Michael E. Debakey Veterans Affairs Medical Center, Houston, Texas, United States of America

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  • Published: April 17, 2007
  • DOI: 10.1371/journal.pmed.0040121

About the Authors

Sarah E Blutt, Sue E Crawford, Berkeley L Bennett, Pedro A Piedra, Margaret E Conner
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
Sarah E Blutt, Margaret E Conner
Michael E. Debakey Veterans Affairs Medical Center, Houston, Texas, United States of America
David O Matson
Center for Pediatric Research, Norfolk, Virginia, United States of America
Mary Allen Staat
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America
Parvin Azimi
Children's Hospital of Oakland, Oakland, California, United States of America

Corresponding Author

Email: mconner@bcm.tmc.edu

Competing Interests

MAS is a member of the advisory boards of GlaxoSmithKline and Merck.

Author Contributions

SEB designed the study, analyzed the data, and wrote the manuscript. DOM provided the samples, assisted in study design, performed statistical analyses, and contributed to writing of the manuscript. SEC provided technical assistance on growing infectious virus and analyzed data. MAS and PA were site principal investigators for the clinical studies that resulted in the collection of the prospective case-surveillance study samples analyzed in this study and contributed to the writing of the manuscript. BLB and PAP provided samples from children with bronchiolitis and assisted in data analysis and writing of the manuscript. MEC assisted in the study design, contributed to writing of the manuscript, and secured funds to support the study.