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Research Article

HIV Patients Developing Primary CNS Lymphoma Lack EBV-Specific CD4+ T Cell Function Irrespective of Absolute CD4+ T Cell Counts

  • Olivier Gasser,

    Affiliation: Immunobiology Laboratory, Department of Research, University Hospital Basel, Basel, Switzerland

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  • Florian K Bihl,

    Affiliation: Partners AIDS Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Marcel Wolbers,

    Affiliation: Institute for Clinical Epidemiology, University Hospital Basel, Basel, Switzerland

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  • Elisabetta Loggi,

    Affiliation: Partners AIDS Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Ingrid Steffen,

    Affiliation: Institute for Medical Microbiology, University of Basel, Basel, Switzerland

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  • Hans H Hirsch,

    Affiliation: Institute for Medical Microbiology, University of Basel, Basel, Switzerland

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  • Huldrych F Günthard,

    Affiliation: Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zürich, Zürich, Switzerland

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  • Bruce D Walker,

    Affiliation: Partners AIDS Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Christian Brander,

    Affiliation: Partners AIDS Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Manuel Battegay,

    Affiliation: Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland

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  • Christoph Hess mail,

    To whom correspondence should be addressed. E-mail: chess@uhbs.ch

    Affiliation: Immunobiology Laboratory, Department of Research, University Hospital Basel, Basel, Switzerland

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  • for the Swiss HIV Cohort Study
  • Published: March 27, 2007
  • DOI: 10.1371/journal.pmed.0040096

About the Authors

Olivier Gasser, Christoph Hess
Immunobiology Laboratory, Department of Research, University Hospital Basel, Basel, Switzerland
Florian K Bihl, Elisabetta Loggi, Bruce D Walker, Christian Brander
Partners AIDS Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Marcel Wolbers
Institute for Clinical Epidemiology, University Hospital Basel, Basel, Switzerland
Ingrid Steffen, Hans H Hirsch
Institute for Medical Microbiology, University of Basel, Basel, Switzerland
Huldrych F Günthard
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zürich, Zürich, Switzerland
Manuel Battegay
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland

Corresponding Author

Email: chess@uhbs.ch

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

OG designed and performed most experiments and helped write the report. FKB, EL, IS, and HHH performed experiments and helped write the report. MW performed statistical analyses and helped writing the report. HFG, BDW, CB, and MB helped design the study, analyzed data, and helped write the report. CH initiated the study, designed the study, analyzed data, and wrote the report.