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Research Article

Dynamics of Polymorphism in a Malaria Vaccine Antigen at a Vaccine-Testing Site in Mali

  • Shannon L Takala,

    Affiliation: Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Drissa Coulibaly,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Mahamadou A Thera,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Alassane Dicko,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • David L Smith,

    Affiliation: Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Ando B Guindo,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Abdoulaye K Kone,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Karim Traore,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Amed Ouattara,

    Affiliations: Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Abdoulaye A Djimde,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Paul S Sehdev,

    Affiliation: Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Kirsten E Lyke,

    Affiliation: Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Dapa A Diallo,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Ogobara K Doumbo,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Christopher V Plowe mail

    To whom correspondence should be addressed. E-mail: cplowe@medicine.umaryland.edu

    Affiliation: Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Published: March 13, 2007
  • DOI: 10.1371/journal.pmed.0040093

About the Authors

Shannon L Takala, Amed Ouattara, Paul S Sehdev, Kirsten E Lyke, Christopher V Plowe
Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
Drissa Coulibaly, Mahamadou A Thera, Alassane Dicko, Ando B Guindo, Abdoulaye K Kone, Karim Traore, Amed Ouattara, Abdoulaye A Djimde, Dapa A Diallo, Ogobara K Doumbo
Malaria Research and Training Center, University of Bamako, Bamako, Mali
David L Smith
Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America

Corresponding Author

Email: cplowe@medicine.umaryland.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SLT designed the genotyping methods, carried out the genotyping, analyzed the data, and wrote the paper. DC was the field team leader and a clinical investigator for this study. DC also enrolled patients and contributed to writing the paper. MAT, AD, ABG, AKK, KT, AO, PSS, KEL, DAD, and OKD designed and conducted the malaria incidence study. DLS designed the haplotype estimating algorithm. AAD contributed to writing the paper. CVP designed the malaria incidence study and assisted with analyzing the data and writing the paper.