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Research Article

Defective Awakening Response to Nocturnal Hypoglycemia in Patients with Type 1 Diabetes Mellitus

  • Bernd Schultes mail,

    To whom correspondence should be addressed. E-mail: schultes@kfg.uni-luebeck.de

    Affiliation: Department of Internal Medicine, University of Luebeck, Luebeck, Germany

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  • Kamila Jauch-Chara,

    Affiliation: Department of Internal Medicine, University of Luebeck, Luebeck, Germany

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  • Steffen Gais,

    Affiliation: Department of Neuroendocrinology, University of Luebeck, Luebeck, Germany

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  • Manfred Hallschmid,

    Affiliation: Department of Neuroendocrinology, University of Luebeck, Luebeck, Germany

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  • Eva Reiprich,

    Affiliation: Department of Internal Medicine, University of Luebeck, Luebeck, Germany

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  • Werner Kern,

    Affiliation: Department of Internal Medicine, University of Luebeck, Luebeck, Germany

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  • Kerstin M Oltmanns,

    Affiliation: Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany

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  • Achim Peters,

    Affiliation: Department of Internal Medicine, University of Luebeck, Luebeck, Germany

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  • Horst L Fehm,

    Affiliation: Department of Internal Medicine, University of Luebeck, Luebeck, Germany

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  • Jan Born

    Affiliation: Department of Neuroendocrinology, University of Luebeck, Luebeck, Germany

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  • Published: February 27, 2007
  • DOI: 10.1371/journal.pmed.0040069

About the Authors

Bernd Schultes, Kamila Jauch-Chara, Eva Reiprich, Werner Kern, Achim Peters, Horst L Fehm
Department of Internal Medicine, University of Luebeck, Luebeck, Germany
Steffen Gais, Manfred Hallschmid, Jan Born
Department of Neuroendocrinology, University of Luebeck, Luebeck, Germany
Kerstin M Oltmanns
Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany

Corresponding Author

Email: schultes@kfg.uni-luebeck.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

BS, SG, WK, KMO, AP, HLF, and JB designed the study. BS, MH, KMO, AP, and JB analyzed the data. KJC, ER, and WK enrolled patients. BS, KJC, SG, MH, ER, WK, KMO, AP, HLF, and JB contributed to writing the paper. SG and ER collected data or did experiments for the study. SG contributed partial analysis of the data and participated in discussions concerning the results. HLF and JB contributed to the conception, design, and data interpretation of the study.