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Research Article

NSAIDs Modulate CDKN2A, TP53, and DNA Content Risk for Progression to Esophageal Adenocarcinoma

  • Patricia C Galipeau equal contributor mail,

    equal contributor Contributed equally to this work with: Patricia C Galipeau, Xiaohong Li

    To whom correspondence should be addressed. E-mail: pgal@fhcrc.org

    Affiliations: Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Xiaohong Li equal contributor,

    equal contributor Contributed equally to this work with: Patricia C Galipeau, Xiaohong Li

    Affiliation: Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Patricia L Blount,

    Affiliations: Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Carlo C Maley,

    Affiliation: Cellular and Molecular Oncogenesis Program, Wistar Institute, Philadelphia, Pennsylvania, United States of America

    X
  • Carissa A Sanchez,

    Affiliations: Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Robert D Odze,

    Affiliation: Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, United States of America

    X
  • Kamran Ayub,

    Affiliation: Department of Gastroenterology, Virginia Mason Medical Center, Seattle, Washington, United States of America

    X
  • Peter S Rabinovitch,

    Affiliations: Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Pathology, University of Washington, Seattle, Washington, United States of America

    X
  • Thomas L Vaughan,

    Affiliations: Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

    X
  • Brian J Reid

    Affiliations: Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Genome Sciences, University of Washington, Seattle, Washington, United States of America

    X
  • Published: February 27, 2007
  • DOI: 10.1371/journal.pmed.0040067

About the Authors

Patricia C Galipeau, Patricia L Blount, Carissa A Sanchez, Peter S Rabinovitch, Brian J Reid
Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Patricia C Galipeau, Xiaohong Li, Patricia L Blount, Carissa A Sanchez, Peter S Rabinovitch, Thomas L Vaughan, Brian J Reid
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Patricia L Blount, Brian J Reid
Department of Medicine, University of Washington, Seattle, Washington, United States of America
Carlo C Maley
Cellular and Molecular Oncogenesis Program, Wistar Institute, Philadelphia, Pennsylvania, United States of America
Robert D Odze
Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Kamran Ayub
Department of Gastroenterology, Virginia Mason Medical Center, Seattle, Washington, United States of America
Peter S Rabinovitch
Department of Pathology, University of Washington, Seattle, Washington, United States of America
Thomas L Vaughan
Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
Brian J Reid
Genome Sciences, University of Washington, Seattle, Washington, United States of America

Corresponding Author

Email: pgal@fhcrc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

PCG, PLB, CAS, TLV, and BJR contributed to conception and design of the study. PCG, PLB, CAS, KA, TLV, and BJR collected data or did experiments for the study. PCG, XL, CCM, CAS, RDO, PSR, TLV, and BJR contributed to analysis and interpretation of the data. PLB and BJR enrolled patients. PCG, XL, PLB, CCM, CAS, RDO, KA, PSR, TLV, and BJR contributed to drafting the article or revising it critically. All authors approved the final accepted version of the manuscript.