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Research Article

Proteomic Profiling of the Amniotic Fluid to Detect Inflammation, Infection, and Neonatal Sepsis

  • Catalin S Buhimschi mail,

    To whom correspondence should be addressed. E-mail: catalin.buhimschi@yale.edu

    Affiliation: Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Vineet Bhandari,

    Affiliation: Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Benjamin D Hamar,

    Affiliation: Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Mert-Ozan Bahtiyar,

    Affiliation: Department of Pediatrics, Division of Perinatal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Guomao Zhao,

    Affiliation: Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Anna K Sfakianaki,

    Affiliation: Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Christian M Pettker,

    Affiliation: Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Lissa Magloire,

    Affiliation: Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Edmund Funai,

    Affiliation: Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Errol R Norwitz,

    Affiliation: Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Michael Paidas,

    Affiliation: Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Joshua A Copel,

    Affiliation: Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Carl P Weiner,

    Affiliation: Department of Obstetrics and Gynecology, University of Kansas School of Medicine, Kansas City, Kansas, United States of America

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  • Charles J Lockwood,

    Affiliation: Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Irina A Buhimschi

    Affiliation: Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Published: January 16, 2007
  • DOI: 10.1371/journal.pmed.0040018

About the Authors

Catalin S Buhimschi, Vineet Bhandari, Benjamin D Hamar, Guomao Zhao, Anna K Sfakianaki, Christian M Pettker, Lissa Magloire, Edmund Funai, Errol R Norwitz, Michael Paidas, Joshua A Copel, Charles J Lockwood, Irina A Buhimschi
Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut, United States of America
Mert-Ozan Bahtiyar
Department of Pediatrics, Division of Perinatal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
Carl P Weiner
Department of Obstetrics and Gynecology, University of Kansas School of Medicine, Kansas City, Kansas, United States of America

Corresponding Author

Email: catalin.buhimschi@yale.edu

Competing Interests

Dr. Irina A. Buhimschi is named co-inventor on a pending patent application related to the use of proteomics analysis of amniotic fluid for diagnosis of preterm delivery. Neither she nor any of the authors served as consultants or received research funds from a third party interested in biomarker discovery including Ciphergen Biosystems.

Author Contributions

CSB and IAB designed the study, collected, analyzed, and interpreted the data, and drafted the manuscript. VB collected, analyzed, and interpreted the neonatal data. GZ conducted ELISA assays and collected part of the proteomics data. BDH, MOB, AKS, CMP, LM, EF, ERN, MP, and JAC recruited patients, collected biological specimens prospectively, and reviewed the data analysis. CPW and CJL participated with aspects of study design and critical interpretation of the data. All authors contributed to writing of the paper and have reviewed and approved the final version.