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Research Article

Angiotensin-Converting Enzyme I/D Polymorphism and Preeclampsia Risk: Evidence of Small-Study Bias

  • Norma C Serrano mail,

    To whom correspondence should be addressed. E-mail: nserrano@unab.edu.co (NCS), Juan.Pablo-Casas@lshtm.ac.uk (JPC)

    Affiliation: Universidad Aut

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  • Luis A Díaz,

    Affiliation: Universidad Aut

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  • Maria C Páez,

    Affiliation: Universidad Aut

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  • Clara M Mesa,

    Affiliation: Instituto de Ciencias de la Salud, Medell

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  • Rodrigo Cifuentes,

    Affiliation: Universidad del Valle, Cali, Colombia

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  • Alvaro Monterrosa,

    Affiliation: Universidad de Cartagena, Cartagena, Colombia

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  • Adriana González,

    Affiliation: Universidad Industrial de Santander, Bucaramanga, Colombia

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  • Liam Smeeth,

    Affiliation: Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, United Kingdom

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  • Aroon D Hingorani,

    Affiliation: Centre for Clinical Pharmacology, Department of Medicine, at British Heart Foundation laboratories at University College London, London, United Kingdom

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  • Juan P Casas mail

    To whom correspondence should be addressed. E-mail: nserrano@unab.edu.co (NCS), Juan.Pablo-Casas@lshtm.ac.uk (JPC)

    Affiliations: Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, United Kingdom, Centre for Clinical Pharmacology, Department of Medicine, at British Heart Foundation laboratories at University College London, London, United Kingdom

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  • Published: December 26, 2006
  • DOI: 10.1371/journal.pmed.0030520

About the Authors

Norma C Serrano, Luis A Díaz, Maria C Páez
Universidad Aut
Clara M Mesa
Instituto de Ciencias de la Salud, Medell
Rodrigo Cifuentes
Universidad del Valle, Cali, Colombia
Alvaro Monterrosa
Universidad de Cartagena, Cartagena, Colombia
Adriana González
Universidad Industrial de Santander, Bucaramanga, Colombia
Liam Smeeth, Juan P Casas
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, United Kingdom
Aroon D Hingorani, Juan P Casas
Centre for Clinical Pharmacology, Department of Medicine, at British Heart Foundation laboratories at University College London, London, United Kingdom

Corresponding Authors

Competing Interests

University College London holds patents on the measurement of asymmetric dimethylarginine in the management of preeclampsia.

Author Contributions

NCS, LAD, MCP, RC, AM, LS, ADH, and JPC designed the study. NCS, LAD, MCP, CMM, AM, AG, LS, and JPC analyzed the data. NCS, MCP, CMM, RC, AM, AG, and LS enrolled patients. NCS, LAD, MCP, CMM, AM, AG, LS, ADH, and JPC contributed to writing the paper. MCP genotyped the insertion/deletion within the angiotensin-converting enzyme gene and collected the data for the meta-analysis.