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Research Article

A Plant-Derived Morphinan as a Novel Lead Compound Active against Malaria Liver Stages

  • Maëlle Carraz,

    Affiliations: Laboratoire de Chimie et Biochimie des Substances Naturelles, Muséum National d'Histoire Naturelle, Paris, France, Inserm U511, Université Pierre et Marie Curie-Paris, Centre Hospitalier Universitaire Pitié-Salpêtrière, Paris, France, Université Pierre et Marie Curie-Paris, Faculté de Médecine Pitié-Salpêtrière, Paris, France

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  • Akino Jossang,

    Affiliation: Laboratoire de Chimie et Biochimie des Substances Naturelles, Muséum National d'Histoire Naturelle, Paris, France

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  • Jean-François Franetich,

    Affiliations: Inserm U511, Université Pierre et Marie Curie-Paris, Centre Hospitalier Universitaire Pitié-Salpêtrière, Paris, France, Université Pierre et Marie Curie-Paris, Faculté de Médecine Pitié-Salpêtrière, Paris, France

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  • Anthony Siau,

    Affiliations: Inserm U511, Université Pierre et Marie Curie-Paris, Centre Hospitalier Universitaire Pitié-Salpêtrière, Paris, France, Université Pierre et Marie Curie-Paris, Faculté de Médecine Pitié-Salpêtrière, Paris, France

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  • Liliane Ciceron,

    Affiliations: Inserm U511, Université Pierre et Marie Curie-Paris, Centre Hospitalier Universitaire Pitié-Salpêtrière, Paris, France, Université Pierre et Marie Curie-Paris, Faculté de Médecine Pitié-Salpêtrière, Paris, France

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  • Laurent Hannoun,

    Affiliation: AP HP, Service de Chirurgie Digestive, Hépato-Bilio-Pancréatique et Transplantation Hépatique, Centre Hospitalo-Universitaire Pitié-Salpêtrière, Paris, France

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  • Robert Sauerwein,

    Affiliation: University Medical Center St. Radboud, Department of Medical Microbiology, Nijmegen, The Netherlands

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  • François Frappier †,

    † Deceased.

    Affiliation: Laboratoire de Chimie et Biochimie des Substances Naturelles, Muséum National d'Histoire Naturelle, Paris, France

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  • Philippe Rasoanaivo,

    Affiliation: Laboratoire de Pharmacognosie Appliquée aux Maladies Infectieuses, Institut Malgache de Recherches Appliquées, Antananarivo, Madagascar

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  • Georges Snounou,

    Affiliation: Laboratoire de Parasitologie Comparée et Modèles Expérimentaux, Muséum National d'Histoire Naturelle, Paris, France

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  • Dominique Mazier mail

    To whom correspondence should be addressed. E-mail: mazier@chups.jussieu.fr

    Affiliations: Inserm U511, Université Pierre et Marie Curie-Paris, Centre Hospitalier Universitaire Pitié-Salpêtrière, Paris, France, Université Pierre et Marie Curie-Paris, Faculté de Médecine Pitié-Salpêtrière, Paris, France, Assistance Publique-Hôpitaux de Paris, Centre Hospitalo-Universitaire Pitié-Salpêtrière, Paris, France

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  • Published: December 26, 2006
  • DOI: 10.1371/journal.pmed.0030513

About the Authors

Maëlle Carraz, Akino Jossang, François Frappier
Laboratoire de Chimie et Biochimie des Substances Naturelles, Muséum National d'Histoire Naturelle, Paris, France
Maëlle Carraz, Jean-François Franetich, Anthony Siau, Liliane Ciceron, Dominique Mazier
Inserm U511, Université Pierre et Marie Curie-Paris, Centre Hospitalier Universitaire Pitié-Salpêtrière, Paris, France
Maëlle Carraz, Jean-François Franetich, Anthony Siau, Liliane Ciceron, Dominique Mazier
Université Pierre et Marie Curie-Paris, Faculté de Médecine Pitié-Salpêtrière, Paris, France
Laurent Hannoun
AP HP, Service de Chirurgie Digestive, Hépato-Bilio-Pancréatique et Transplantation Hépatique, Centre Hospitalo-Universitaire Pitié-Salpêtrière, Paris, France
Robert Sauerwein
University Medical Center St. Radboud, Department of Medical Microbiology, Nijmegen, The Netherlands
Philippe Rasoanaivo
Laboratoire de Pharmacognosie Appliquée aux Maladies Infectieuses, Institut Malgache de Recherches Appliquées, Antananarivo, Madagascar
Georges Snounou
Laboratoire de Parasitologie Comparée et Modèles Expérimentaux, Muséum National d'Histoire Naturelle, Paris, France
Dominique Mazier
Assistance Publique-Hôpitaux de Paris, Centre Hospitalo-Universitaire Pitié-Salpêtrière, Paris, France

Corresponding Author

Email: mazier@chups.jussieu.fr

Competing Interests

Patents have been filed on compounds mentioned in this paper: Priority Europe No 04 291 055.4 April 22 2004; International Patent Application 21 April 2005 No PCT/EP 2005/005239 (MC, JFF, AJ, FF, PR, and DM). The authors have declared that no competing interests exist.

Author Contributions

MC assisted in the experimental design, carried out the bulk of the experimental work, and contributed significantly to the composition of the manuscript. FF, PR, and DM initiated the project. AJ and FF directed the chemical aspects of the work, while GS and DM directed the biological facets of the work, and composed the manuscript. JFF supervised and significantly helped with much of the biological experimental investigations. AS and LC helped with some of the experimental work. LH, RS, and PR provided essential materials. FF, listed as an author of this paper, died before its publication. The corresponding author, DM, has therefore supplied the information regarding his contribution to the manuscript and his competing interests, and it is correct to the best of her knowledge.