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Research Article

Lipoprotein Particle Profiles Mark Familial and Sporadic Human Longevity

  • Bastiaan T Heijmans mail,

    To whom correspondence should be addressed. E-mail: b.t.heijmans@lumc.nl

    Affiliation: Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands

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  • Marian Beekman,

    Affiliation: Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands

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  • Jeanine J Houwing-Duistermaat,

    Affiliation: Department of Medical Statistics, Leiden University Medical Centre, Leiden, The Netherlands

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  • Mark R Cobain,

    Affiliation: Unilever Corporate Research, Colworth Laboratory, Sharnbrook, Bedford, United Kingdom

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  • Jonathan Powell,

    Affiliation: Unilever Corporate Research, Colworth Laboratory, Sharnbrook, Bedford, United Kingdom

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  • Gerard Jan Blauw,

    Affiliation: Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The Netherlands

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  • Frans van der Ouderaa,

    Affiliation: Unilever Corporate Research, Colworth Laboratory, Sharnbrook, Bedford, United Kingdom

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  • Rudi G. J Westendorp,

    Affiliation: Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The Netherlands

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  • P. Eline Slagboom

    Affiliation: Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands

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  • Published: December 26, 2006
  • DOI: 10.1371/journal.pmed.0030495

About the Authors

Bastiaan T Heijmans, Marian Beekman, P. Eline Slagboom
Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
Jeanine J Houwing-Duistermaat
Department of Medical Statistics, Leiden University Medical Centre, Leiden, The Netherlands
Mark R Cobain, Jonathan Powell, Frans van der Ouderaa
Unilever Corporate Research, Colworth Laboratory, Sharnbrook, Bedford, United Kingdom
Gerard Jan Blauw, Rudi G. J Westendorp
Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The Netherlands

Corresponding Author

Email: b.t.heijmans@lumc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

GJB, FvdO, RGJW, and PES designed the study. BTH, MB, JJHD RGJW, and PES analyzed the data. GJB enrolled patients. BTH, MB, JJHD, MRC, JP, GJB, FvdO, RGJW, and PES contributed to writing the paper. GJB and PES collected data or did experiments for the study. MB coordinated the shipment of the sera of the individuals in the study to LipoScience for lipoprotein particle size. JP collected and assembled the LDL particle size data via Liposcience.