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Research Article

Dominance of HIV-1 Subtype CRF01_AE in Sexually Acquired Cases Leads to a New Epidemic in Yunnan Province of China

  • Yong Zhang,

    Affiliation: Yunnan Center for Disease Control and Prevention, Kunming, Yunnan, People's Republic of China

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  • Lin Lu,

    Affiliation: Yunnan Center for Disease Control and Prevention, Kunming, Yunnan, People's Republic of China

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  • Lei Ba,

    Affiliation: Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York, United States of America

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  • Li Liu,

    Affiliations: Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York, United States of America, State Key Laboratory of Virology, Modern Virology Research Center and AIDS Center, Wuhan University, Wuhan, Hubei, People's Republic of China

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  • Li Yang,

    Affiliation: Yunnan Center for Disease Control and Prevention, Kunming, Yunnan, People's Republic of China

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  • Manhong Jia,

    Affiliation: Yunnan Center for Disease Control and Prevention, Kunming, Yunnan, People's Republic of China

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  • Haibo Wang,

    Affiliation: State Key Laboratory of Virology, Modern Virology Research Center and AIDS Center, Wuhan University, Wuhan, Hubei, People's Republic of China

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  • Qing Fang,

    Affiliation: Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York, United States of America

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  • Yuhua Shi,

    Affiliation: Yunnan Center for Disease Control and Prevention, Kunming, Yunnan, People's Republic of China

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  • Wenyun Yan,

    Affiliation: Yunnan Center for Disease Control and Prevention, Kunming, Yunnan, People's Republic of China

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  • Guangcai Chang,

    Affiliation: Yunnan Center for Disease Control and Prevention, Kunming, Yunnan, People's Republic of China

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  • Linqi Zhang,

    Affiliations: Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York, United States of America, State Key Laboratory of Virology, Modern Virology Research Center and AIDS Center, Wuhan University, Wuhan, Hubei, People's Republic of China

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  • David D Ho,

    Affiliation: Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York, United States of America

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  • Zhiwei Chen mail

    To whom correspondence should be addressed. E-mail: zchen@adarc.org

    Affiliations: Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York, United States of America, State Key Laboratory of Virology, Modern Virology Research Center and AIDS Center, Wuhan University, Wuhan, Hubei, People's Republic of China

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  • Published: November 14, 2006
  • DOI: 10.1371/journal.pmed.0030443

About the Authors

Yong Zhang, Lin Lu, Li Yang, Manhong Jia, Yuhua Shi, Wenyun Yan, Guangcai Chang
Yunnan Center for Disease Control and Prevention, Kunming, Yunnan, People's Republic of China
Lei Ba, Li Liu, Qing Fang, Linqi Zhang, David D Ho, Zhiwei Chen
Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York, United States of America
Li Liu, Haibo Wang, Linqi Zhang, Zhiwei Chen
State Key Laboratory of Virology, Modern Virology Research Center and AIDS Center, Wuhan University, Wuhan, Hubei, People's Republic of China

Corresponding Author

Email: zchen@adarc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Z. Chen designed the study. L. Zhang, D. Ho, and Z. Chen analyzed the data. Z. Chen wrote the paper with contributions from Y. Zhang, L. Zhang, and D. Ho. Y. Zhang, L. Lu, L. Yang, M. Jia, Y. Shi, W. Yan, and G. Chang did sample collection, ELISA, Western Blot, viral RNA extraction, PCR, and data collection as well as taking part in discussions. L. Ba, L. Liu, H. Wang, Q. Fang, and Z. Chen did RT-PCR, PCR product purification, and sequencing reactions. Y. Zhang, L. Lu, and M. Jia collected and analyzed surveillance data from 80 sentinel sites and 16 prefectures. D. Ho and Z. Chen provided overall project coordination.