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Research Article

Complement Lysis Activity in Autologous Plasma Is Associated with Lower Viral Loads during the Acute Phase of HIV-1 Infection

  • Michael Huber,

    Affiliation: Division of Infectious Diseases, University Hospital Zürich, Zürich, Switzerland

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  • Marek Fischer,

    Affiliation: Division of Infectious Diseases, University Hospital Zürich, Zürich, Switzerland

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  • Benjamin Misselwitz,

    Affiliation: Division of Infectious Diseases, University Hospital Zürich, Zürich, Switzerland

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  • Amapola Manrique,

    Affiliation: Division of Infectious Diseases, University Hospital Zürich, Zürich, Switzerland

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  • Herbert Kuster,

    Affiliation: Division of Infectious Diseases, University Hospital Zürich, Zürich, Switzerland

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  • Barbara Niederöst,

    Affiliation: Division of Infectious Diseases, University Hospital Zürich, Zürich, Switzerland

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  • Rainer Weber,

    Affiliation: Division of Infectious Diseases, University Hospital Zürich, Zürich, Switzerland

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  • Viktor von Wyl,

    Affiliation: Division of Infectious Diseases, University Hospital Zürich, Zürich, Switzerland

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  • Huldrych F Günthard,

    Affiliation: Division of Infectious Diseases, University Hospital Zürich, Zürich, Switzerland

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  • Alexandra Trkola mail

    To whom correspondence should be addressed. E-mail: alexandra.trkola@usz.ch

    Affiliation: Division of Infectious Diseases, University Hospital Zürich, Zürich, Switzerland

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  • Published: November 21, 2006
  • DOI: 10.1371/journal.pmed.0030441

About the Authors

Michael Huber, Marek Fischer, Benjamin Misselwitz, Amapola Manrique, Herbert Kuster, Barbara Niederöst, Rainer Weber, Viktor von Wyl, Huldrych F Günthard, Alexandra Trkola
Division of Infectious Diseases, University Hospital Zürich, Zürich, Switzerland

Corresponding Author

Email: alexandra.trkola@usz.ch

Competing Interests

The authors declare that no competing interests exist.

Author Contributions

MH, MF, HFG, and AT designed the study. MH, MF, VvW, and AT analyzed the data. RW and HFG enrolled patients. MH, MF, AM, HK, RW, VvW, HFG, and AT contributed to writing the paper. BM developed the assay for the determination of GP41 antibody titers, determined all the antibody titers (anti-gp41, anti-gp120, and anti-p24), and analyzed these data. AM provided an experimental contribution to assays. HK performed virus isolations and neutralization assays and determined plasma IgG titers. BN performed RNA extractions and real-time PCRs. RW contributed to the design of the clinical studies and collection of patients' data. HFG designed and conducted the clinical studies forming the base for this laboratory work and was significantly involved in the overall design of this investigation.