Advertisement
Research Article

Targeted Killing of Virally Infected Cells by Radiolabeled Antibodies to Viral Proteins

  • Ekaterina Dadachova mail,

    To whom correspondence should be addressed. E-mail: edadacho@aecom.yu.edu

    Affiliation: Albert Einstein College of Medicine, Bronx, New York, United States of America

    X
  • Mahesh C Patel,

    Affiliations: Albert Einstein College of Medicine, Bronx, New York, United States of America, Jacobi Medical Center, Bronx, New York, United States of America

    X
  • Sima Toussi,

    Affiliation: Albert Einstein College of Medicine, Bronx, New York, United States of America

    X
  • Christos Apostolidis,

    Affiliation: European Commission, Joint Research Centre, Institute for Transuranium Elements, Karlsruhe, Germany

    X
  • Alfred Morgenstern,

    Affiliation: European Commission, Joint Research Centre, Institute for Transuranium Elements, Karlsruhe, Germany

    X
  • Martin W Brechbiel,

    Affiliation: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Miroslaw K Gorny,

    Affiliation: New York University School of Medicine, New York, New York, United States of America

    X
  • Susan Zolla-Pazner,

    Affiliations: New York University School of Medicine, New York, New York, United States of America, Veterans Affairs New York Harbor Healthcare System, New York, New York, United States of America

    X
  • Arturo Casadevall,

    Affiliation: Albert Einstein College of Medicine, Bronx, New York, United States of America

    X
  • Harris Goldstein

    Affiliation: Albert Einstein College of Medicine, Bronx, New York, United States of America

    X
  • Published: November 07, 2006
  • DOI: 10.1371/journal.pmed.0030427

About the Authors

Ekaterina Dadachova, Mahesh C Patel, Sima Toussi, Arturo Casadevall, Harris Goldstein
Albert Einstein College of Medicine, Bronx, New York, United States of America
Mahesh C Patel
Jacobi Medical Center, Bronx, New York, United States of America
Christos Apostolidis, Alfred Morgenstern
European Commission, Joint Research Centre, Institute for Transuranium Elements, Karlsruhe, Germany
Martin W Brechbiel
National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Miroslaw K Gorny, Susan Zolla-Pazner
New York University School of Medicine, New York, New York, United States of America
Susan Zolla-Pazner
Veterans Affairs New York Harbor Healthcare System, New York, New York, United States of America

Corresponding Author

Email: edadacho@aecom.yu.edu

Competing Interests

AC and ED are consultants for Pain Therapeutics on a project unrelated to the work described in the manuscript. The relationship with the company involves monetary compensation for our advice, reimbursement for company related travel, and share options. The patent application for the treatment of HIV/AIDS with RIT has been licensed by Albert Einstein College of Medicine to Pain Therapeutics.

Author Contributions

AC provided the idea for this study. ED, MCP, AC, SZP and HG designed the study. ED, MCP, ST, SZP, AC, and HG analyzed the data. ED, MCP, MWB, MKG, SZP, AC, and HG contributed to writing the paper. CA and AM supplied 225Ac/213Bi radionuclide generators. MWB synthesized and provided the bifunctional chelating agent that was used for these studies. MKG did the following experiments for the study: binding of the human monoclonal antibodies 246, 447, and 1418 to hPBMCs infected with HIV-1JR-CSF. SZP and MKG produced and provided human monoclonal antibodies 246-D, 447, and 1418.