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Research Article

Methods of Blinding in Reports of Randomized Controlled Trials Assessing Pharmacologic Treatments: A Systematic Review

  • Isabelle Boutron mail,

    To whom correspondence should be addressed. E-mail: isabelle.boutron@bch.ap-hop-paris.fr

    Affiliations: INSERM U738, Paris, France, Université Paris 7, UFR de Médecine, Paris, France, AP-HP, Hópital Bichat, Département d'Epidémiologie, Biostatistique et Recherche Clinique, Paris, France

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  • Candice Estellat,

    Affiliations: INSERM U738, Paris, France, Université Paris 7, UFR de Médecine, Paris, France, AP-HP, Hópital Bichat, Département d'Epidémiologie, Biostatistique et Recherche Clinique, Paris, France

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  • Lydia Guittet,

    Affiliations: INSERM U738, Paris, France, Université Paris 7, UFR de Médecine, Paris, France, AP-HP, Hópital Bichat, Département d'Epidémiologie, Biostatistique et Recherche Clinique, Paris, France

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  • Agnes Dechartres,

    Affiliations: INSERM U738, Paris, France, Université Paris 7, UFR de Médecine, Paris, France, AP-HP, Hópital Bichat, Département d'Epidémiologie, Biostatistique et Recherche Clinique, Paris, France

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  • David L Sackett,

    Affiliation: Trout Research and Education Centre at Irish Lake, Markdale, Ontario, Canada

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  • Asbjørn Hróbjartsson,

    Affiliation: Nordic Cochrane Centre, Rigshospitalet, Copenhagen, Denmark

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  • Philippe Ravaud

    Affiliations: INSERM U738, Paris, France, Université Paris 7, UFR de Médecine, Paris, France, AP-HP, Hópital Bichat, Département d'Epidémiologie, Biostatistique et Recherche Clinique, Paris, France

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  • Published: October 31, 2006
  • DOI: 10.1371/journal.pmed.0030425

About the Authors

Isabelle Boutron, Candice Estellat, Lydia Guittet, Agnes Dechartres, Philippe Ravaud
INSERM U738, Paris, France
Isabelle Boutron, Candice Estellat, Lydia Guittet, Agnes Dechartres, Philippe Ravaud
Université Paris 7, UFR de Médecine, Paris, France
Isabelle Boutron, Candice Estellat, Lydia Guittet, Agnes Dechartres, Philippe Ravaud
AP-HP, Hópital Bichat, Département d'Epidémiologie, Biostatistique et Recherche Clinique, Paris, France
David L Sackett
Trout Research and Education Centre at Irish Lake, Markdale, Ontario, Canada
Asbjørn Hróbjartsson
Nordic Cochrane Centre, Rigshospitalet, Copenhagen, Denmark

Corresponding Author

Email: isabelle.boutron@bch.ap-hop-paris.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

IB, DLS, AH, and PR designed the study. IB analyzed the data. IB, CE, LG, LG, AD, DLS, AH, and PR contributed to writing the paper. IB, CE, LG, and AD collected data or did experiments for the study.