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Research Article

Analysis of Gene Expression Using Gene Sets Discriminates Cancer Patients with and without Late Radiation Toxicity

  • J. Peter Svensson,

    Affiliations: Department of Toxicogenetics, Leiden University Medical Center, Leiden, Netherlands, Department of Oncology, Radiology, and Clinical Immunology, Academic Hospital, Uppsala, Sweden

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  • Lukas J. A Stalpers,

    Affiliation: Department of Radiotherapy/LEXOR Laboratory of Experimental Oncology and Radiobiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands

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  • Rebecca E. E. Esveldt–van Lange,

    Affiliation: Department of Toxicogenetics, Leiden University Medical Center, Leiden, Netherlands

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  • Nicolaas A. P Franken,

    Affiliation: Department of Radiotherapy/LEXOR Laboratory of Experimental Oncology and Radiobiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands

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  • Jaap Haveman,

    Affiliation: Department of Radiotherapy/LEXOR Laboratory of Experimental Oncology and Radiobiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands

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  • Binie Klein,

    Affiliation: Department of Toxicogenetics, Leiden University Medical Center, Leiden, Netherlands

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  • Ingela Turesson,

    Affiliation: Department of Oncology, Radiology, and Clinical Immunology, Academic Hospital, Uppsala, Sweden

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  • Harry Vrieling,

    Affiliation: Department of Toxicogenetics, Leiden University Medical Center, Leiden, Netherlands

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  • Micheline Giphart-Gassler mail

    To whom correspondence should be addressed. E-mail: m.giphart-gassler@lumc.nl

    Affiliation: Department of Toxicogenetics, Leiden University Medical Center, Leiden, Netherlands

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  • Published: October 31, 2006
  • DOI: 10.1371/journal.pmed.0030422

About the Authors

J. Peter Svensson, Rebecca E. E. Esveldt–van Lange, Binie Klein, Harry Vrieling, Micheline Giphart-Gassler
Department of Toxicogenetics, Leiden University Medical Center, Leiden, Netherlands
J. Peter Svensson, Ingela Turesson
Department of Oncology, Radiology, and Clinical Immunology, Academic Hospital, Uppsala, Sweden
Lukas J. A Stalpers, Nicolaas A. P Franken, Jaap Haveman
Department of Radiotherapy/LEXOR Laboratory of Experimental Oncology and Radiobiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands

Corresponding Author

Email: m.giphart-gassler@lumc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

LJAS, NAPF, JH, HV, and MGG initiated the study. LJAS, NAPF, and JH enrolled patients and collected clinical material. LJAS analyzed clinical data. JPS, REEEvL, and BK did the laboratory experiments. JPS analyzed the gene expression data. HV, LJAS, and MGG supervised the study. JPS, LJAS, NAPF, JH, IT, HV, and MGG contributed to writing the paper.