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Research Article

Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer

  • Anju Singh,

    Affiliation: Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Vikas Misra,

    Affiliation: Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Rajesh K Thimmulappa,

    Affiliation: Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Hannah Lee,

    Affiliation: Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Stephen Ames,

    Affiliation: Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Mohammad O Hoque,

    Affiliation: Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • James G Herman,

    Affiliation: Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Stephen B Baylin,

    Affiliation: Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • David Sidransky,

    Affiliations: Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Edward Gabrielson,

    Affiliation: Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Malcolm V Brock,

    Affiliation: Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Shyam Biswal mail

    To whom correspondence should be addressed. E-mail: sbiswal@jhsph.edu

    Affiliations: Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America, Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Published: October 03, 2006
  • DOI: 10.1371/journal.pmed.0030420

About the Authors

Anju Singh, Vikas Misra, Rajesh K Thimmulappa, Hannah Lee, Shyam Biswal
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
Stephen Ames, James G Herman, Stephen B Baylin, David Sidransky, Edward Gabrielson, Malcolm V Brock, Shyam Biswal
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America
Mohammad O Hoque, David Sidransky
Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland, United States of America
Shyam Biswal
Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

Corresponding Author

Email: sbiswal@jhsph.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AS, SBB, and SB designed the experiments. AS, VM, RKT, HL, SA, and EG performed the experiments. AS, MOH, DS, and SB were involved in data analysis. MB was involved in collection and maintenance of all the human tissue samples. JGH provided all the cancer cell lines. SB contributed reagents/materials. AS, JGH, SBB, DS, and SB contributed to writing the paper.