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Research Article

Live, Attenuated Influenza A H5N1 Candidate Vaccines Provide Broad Cross-Protection in Mice and Ferrets

  • Amorsolo L Suguitan Jr. equal contributor,

    equal contributor Contributed equally to this work with: Amorsolo L Suguitan Jr., Josephine McAuliffe

    Affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Josephine McAuliffe equal contributor,

    equal contributor Contributed equally to this work with: Amorsolo L Suguitan Jr., Josephine McAuliffe

    Affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Kimberly L Mills,

    Affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Hong Jin,

    Affiliation: MedImmune Vaccines, Mountain View, California, United States of America

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  • Greg Duke,

    Affiliation: MedImmune Vaccines, Mountain View, California, United States of America

    X
  • Bin Lu,

    Affiliation: MedImmune Vaccines, Mountain View, California, United States of America

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  • Catherine J Luke,

    Affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Brian Murphy,

    Affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • David E Swayne,

    Affiliation: Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, Athens, Georgia, United States of America

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  • George Kemble,

    Affiliation: MedImmune Vaccines, Mountain View, California, United States of America

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  • Kanta Subbarao mail

    To whom correspondence should be addressed. E-mail: ksubbarao@niaid.nih.gov

    Affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: September 12, 2006
  • DOI: 10.1371/journal.pmed.0030360

About the Authors

Amorsolo L Suguitan Jr., Josephine McAuliffe, Kimberly L Mills, Catherine J Luke, Brian Murphy, Kanta Subbarao
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Hong Jin, Greg Duke, Bin Lu, George Kemble
MedImmune Vaccines, Mountain View, California, United States of America
David E Swayne
Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, Athens, Georgia, United States of America

Corresponding Author

Email: ksubbarao@niaid.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

BM, GK, and KS conceived the idea and were the lab chief of the NIH team and principal investigators of the NIH and MedImmune teams, respectively. JM, HJ, GD, BL, and KS produced recombinant cDNAs and rescued the viruses by reverse genetics. ALS, JM, KLM, and KS performed the mouse and ferret studies. DES was responsible for evaluation of the viruses in chickens and CEF cells. BM advised on the preparation of the manuscript. ALS, CJL, and KS wrote the article, with input from all of the authors. All of the authors participated in analysis and interpretation of the data.