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Research Article

In Celiac Disease, a Subset of Autoantibodies against Transglutaminase Binds Toll-Like Receptor 4 and Induces Activation of Monocytes

  • Giovanna Zanoni equal contributor,

    equal contributor Contributed equally to this work with: Giovanna Zanoni, Riccardo Navone, Claudio Lunardi

    Affiliation: Section of Immunology, Department of Pathology, University of Verona, Verona, Italy

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  • Riccardo Navone equal contributor,

    equal contributor Contributed equally to this work with: Giovanna Zanoni, Riccardo Navone, Claudio Lunardi

    Affiliation: Section of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy

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  • Claudio Lunardi equal contributor mail,

    equal contributor Contributed equally to this work with: Giovanna Zanoni, Riccardo Navone, Claudio Lunardi

    To whom correspondence should be addressed. E-mail: claudio.lunardi@univr.it

    Affiliation: Section of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy

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  • Giuseppe Tridente,

    Affiliation: Section of Immunology, Department of Pathology, University of Verona, Verona, Italy

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  • Caterina Bason,

    Affiliation: Section of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy

    X
  • Simona Sivori,

    Affiliation: Section of Histology, Department of Experimental Medicine, University of Genova, Genova, Italy

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  • Ruggero Beri,

    Affiliation: Section of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy

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  • Marzia Dolcino,

    Affiliation: Immunology Unit, Institute G. Gaslini, Genova, Italy

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  • Enrico Valletta,

    Affiliation: Department of Pediatrics, University Hospital of Verona, Verona, Italy

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  • Roberto Corrocher,

    Affiliation: Section of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy

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  • Antonio Puccetti

    Affiliations: Section of Histology, Department of Experimental Medicine, University of Genova, Genova, Italy, Immunology Unit, Institute G. Gaslini, Genova, Italy

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  • Published: September 19, 2006
  • DOI: 10.1371/journal.pmed.0030358

About the Authors

Giovanna Zanoni, Giuseppe Tridente
Section of Immunology, Department of Pathology, University of Verona, Verona, Italy
Riccardo Navone, Claudio Lunardi, Caterina Bason, Ruggero Beri, Roberto Corrocher
Section of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
Simona Sivori, Antonio Puccetti
Section of Histology, Department of Experimental Medicine, University of Genova, Genova, Italy
Marzia Dolcino, Antonio Puccetti
Immunology Unit, Institute G. Gaslini, Genova, Italy
Enrico Valletta
Department of Pediatrics, University Hospital of Verona, Verona, Italy

Corresponding Author

Email: claudio.lunardi@univr.it

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

GZ, CL, and AP conceived the idea and were the principal investigators of the Verona and Genova teams, respectively. RN screened the peptide library and performed the majority of the experiments. CB was responsible for purification of the antibodies. RB performed some of the ELISA tests. MD synthesized the peptides used throughout the study. SS performed the FACS analysis. EV was responsible for the pediatric patients selection. GT and RC advised on the preparation of the report. CL and AP wrote the article with input from GZ.