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Research Article

A Multicentre Study of Shigella Diarrhoea in Six Asian Countries: Disease Burden, Clinical Manifestations, and Microbiology

  • Lorenz von Seidlein mail,

    To whom correspondence should be addressed. E-mail: lseidlein@ivi.int

    Affiliation: International Vaccine Institute, Seoul, Korea

    X
  • Deok Ryun Kim,

    Affiliation: International Vaccine Institute, Seoul, Korea

    X
  • Mohammad Ali,

    Affiliation: International Vaccine Institute, Seoul, Korea

    X
  • Hyejon Lee,

    Affiliation: International Vaccine Institute, Seoul, Korea

    X
  • XuanYi Wang,

    Affiliations: International Vaccine Institute, Seoul, Korea, Fudan University, Shanghai, China

    X
  • Vu Dinh Thiem,

    Affiliation: National Institute of Hygiene and Epidemiology, Hanoi, Vietnam

    X
  • Do Gia Canh,

    Affiliation: National Institute of Hygiene and Epidemiology, Hanoi, Vietnam

    X
  • Wanpen Chaicumpa,

    Affiliation: Faculty of Allied Health Sciences, Thammasat University, Rangsit Center, Patumthani, Thailand

    X
  • Magdarina D Agtini,

    Affiliation: National Institute of Health Research and Development, Jakarta Indonesia, Ministry of Health, Jakarta, Indonesia

    X
  • Anowar Hossain,

    Affiliation: Centre for Health and Population Research, Dhaka, Bangladesh

    X
  • Zulfiqar A Bhutta,

    Affiliation: Department of Paediatrics, The Aga Khan University, Karachi, Pakistan

    X
  • Carl Mason,

    Affiliation: United States Armed Forces Research Institute for Medical Sciences, Bangkok, Thailand

    X
  • Ornthipa Sethabutr,

    Affiliation: United States Armed Forces Research Institute for Medical Sciences, Bangkok, Thailand

    X
  • Kaisar Talukder,

    Affiliation: Centre for Health and Population Research, Dhaka, Bangladesh

    X
  • G. B Nair,

    Affiliation: Centre for Health and Population Research, Dhaka, Bangladesh

    X
  • Jacqueline L Deen,

    Affiliation: International Vaccine Institute, Seoul, Korea

    X
  • Karen Kotloff,

    Affiliation: Centers for Vaccine Development, Baltimore, Maryland, United States of America

    X
  • John Clemens

    Affiliation: International Vaccine Institute, Seoul, Korea

    X
  • Published: September 12, 2006
  • DOI: 10.1371/journal.pmed.0030353

About the Authors

Lorenz von Seidlein, Deok Ryun Kim, Mohammad Ali, Hyejon Lee, XuanYi Wang, Jacqueline L Deen, John Clemens
International Vaccine Institute, Seoul, Korea
XuanYi Wang
Fudan University, Shanghai, China
Vu Dinh Thiem, Do Gia Canh
National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
Wanpen Chaicumpa
Faculty of Allied Health Sciences, Thammasat University, Rangsit Center, Patumthani, Thailand
Magdarina D Agtini
National Institute of Health Research and Development, Jakarta Indonesia, Ministry of Health, Jakarta, Indonesia
Anowar Hossain, Kaisar Talukder, G. B Nair
Centre for Health and Population Research, Dhaka, Bangladesh
Zulfiqar A Bhutta
Department of Paediatrics, The Aga Khan University, Karachi, Pakistan
Carl Mason, Ornthipa Sethabutr
United States Armed Forces Research Institute for Medical Sciences, Bangkok, Thailand
Karen Kotloff
Centers for Vaccine Development, Baltimore, Maryland, United States of America

Corresponding Author

Email: lseidlein@ivi.int

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

LvS coordinated the studies in the six countries and wrote the first draft of this paper. DRK was responsible for the analysis. MA developed and managed the database. HL coordinated the microbiological aspects of the project. XYW, WC, MDA, AH, and ZAB were the principal investigators responsible for the drafting, adaptation, and implementations of the study protocol. VDT coordinated the study site in Vietnam. CM and OS processed the PCR specimens and analyzed the findings. KT was responsible for the analysis of S. flexneri isolates that did not agglutinate with commercial serotypes. GBN provided advice on the interpretation of monoclonal serotype results and PCR findings. JLD and KK provided essential support for the interpretation of the data. JC conceived the project, attracted funding, and oversaw all stages of the project. All authors contributed to the writing of the final version of this paper.