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Research Article

Regulation of Peripheral Inflammation by Spinal p38 MAP Kinase in Rats

  • David L Boyle,

    Affiliation: Division of Rheumatology, Allergy, and Immunology, University of California San Diego School of Medicine, La Jolla, California, United States of America

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  • Toni L Jones,

    Affiliation: Department of Anesthesiology, University of California San Diego School of Medicine, La Jolla, California, United States of America

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  • Deepa Hammaker,

    Affiliation: Division of Rheumatology, Allergy, and Immunology, University of California San Diego School of Medicine, La Jolla, California, United States of America

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  • Camille I Svensson,

    Affiliation: Department of Anesthesiology, University of California San Diego School of Medicine, La Jolla, California, United States of America

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  • Sanna Rosengren,

    Affiliation: Division of Rheumatology, Allergy, and Immunology, University of California San Diego School of Medicine, La Jolla, California, United States of America

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  • Salvatore Albani,

    Affiliation: Division of Rheumatology, Allergy, and Immunology, University of California San Diego School of Medicine, La Jolla, California, United States of America

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  • Linda Sorkin,

    Affiliation: Department of Anesthesiology, University of California San Diego School of Medicine, La Jolla, California, United States of America

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  • Gary S Firestein mail

    To whom correspondence should be addressed. E-mail: gfirestein@ucsd.edu

    Affiliation: Division of Rheumatology, Allergy, and Immunology, University of California San Diego School of Medicine, La Jolla, California, United States of America

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  • Published: September 05, 2006
  • DOI: 10.1371/journal.pmed.0030338

About the Authors

David L Boyle, Deepa Hammaker, Sanna Rosengren, Salvatore Albani, Gary S Firestein
Division of Rheumatology, Allergy, and Immunology, University of California San Diego School of Medicine, La Jolla, California, United States of America
Toni L Jones, Camille I Svensson, Linda Sorkin
Department of Anesthesiology, University of California San Diego School of Medicine, La Jolla, California, United States of America

Corresponding Author

Email: gfirestein@ucsd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

DLB, SA, LS, and GSF designed the study. DLB, TLJ, LS, and GSF analyzed the data. DLB, CIS, LS, and GSF contributed to writing the paper. DH performed some of the Western blotting experiments discussed in the paper, and SR performed some of the in vivo studies.