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Research Article

Inflammatory Cytokines as Risk Factors for a First Venous Thrombosis: A Prospective Population-Based Study

  • Sverre C Christiansen,

    Affiliation: Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands

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  • Inger Anne Næss,

    Affiliation: Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway

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  • Suzanne C Cannegieter,

    Affiliation: Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands

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  • Jens Hammerstrøm,

    Affiliation: Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway

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  • Frits R Rosendaal,

    Affiliations: Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands, Department of Haematology, Leiden University Medical Center, Leiden, Netherlands

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  • Pieter H Reitsma mail

    To whom correspondence should be addressed. E-mail: p.h.reitsma@amc.uva.nl

    Affiliation: Laboratory for Experimental Internal Medicine, Academic Medical Center, Amsterdam, Netherlands

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  • Published: August 22, 2006
  • DOI: 10.1371/journal.pmed.0030334

About the Authors

Sverre C Christiansen, Suzanne C Cannegieter, Frits R Rosendaal
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Inger Anne Næss, Jens Hammerstrøm
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Frits R Rosendaal
Department of Haematology, Leiden University Medical Center, Leiden, Netherlands
Pieter H Reitsma
Laboratory for Experimental Internal Medicine, Academic Medical Center, Amsterdam, Netherlands

Corresponding Author

Email: p.h.reitsma@amc.uva.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

All authors participated in the design of this study within HUNT2. S. Christiansen, I. Næss, and J. Hammerstrøm were responsible, in Norway, for data and sample collection from the study participants and for making these available for analysis. P. Reitsma was responsible for the cytokine assays. S. Christiansen and S. Cannegieter were responsible for collecting and analyzing the cytokine data. All authors participated in writing the paper and approved the final version of the manuscript.