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Research Article

Acute-Phase Serum Amyloid A: An Inflammatory Adipokine and Potential Link between Obesity and Its Metabolic Complications

  • Rong-Ze Yang,

    Affiliation: Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Mi-Jeong Lee,

    Affiliation: Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Hong Hu,

    Affiliation: Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Toni I Pollin,

    Affiliation: Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Alice S Ryan,

    Affiliation: Division of Gerontology, Geriatric Research, Education, and Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland, United States of America

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  • Barbara J Nicklas,

    Affiliation: Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Soren Snitker,

    Affiliation: Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Richard B Horenstein,

    Affiliation: Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Kristen Hull,

    Affiliation: Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Nelson H Goldberg,

    Affiliation: Division of Plastic and Reconstructive Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Andrew P Goldberg,

    Affiliation: Division of Gerontology, Geriatric Research, Education, and Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland, United States of America

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  • Alan R Shuldiner,

    Affiliations: Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Division of Gerontology, Geriatric Research, Education, and Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland, United States of America

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  • Susan K Fried,

    Affiliations: Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Division of Gerontology, Geriatric Research, Education, and Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland, United States of America

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  • Da-Wei Gong mail

    To whom correspondence should be addressed. E-mail: dgong@medicine.umaryland.edu

    Affiliation: Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Published: June 06, 2006
  • DOI: 10.1371/journal.pmed.0030287

About the Authors

Rong-Ze Yang, Mi-Jeong Lee, Hong Hu, Toni I Pollin, Soren Snitker, Richard B Horenstein, Kristen Hull, Alan R Shuldiner, Susan K Fried, Da-Wei Gong
Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
Alice S Ryan, Andrew P Goldberg, Alan R Shuldiner, Susan K Fried
Division of Gerontology, Geriatric Research, Education, and Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland, United States of America
Barbara J Nicklas
Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
Nelson H Goldberg
Division of Plastic and Reconstructive Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

Corresponding Author

Email: dgong@medicine.umaryland.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

RZY, MJL, ASR, BJN, APG, ARS, SKF, and DWG designed the study. RZY, MJL, HH, ASR, BJN, SS, RBH, KH, NHG, and DWG performed the experiments. RZY, MJL, TIP, ASR, BJN, and DWG analyzed the data. RZY, MJL, ASR, BJN, RBH, APG, ARS, SKF, and DWG contributed to writing the paper.