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Research Article

MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia

  • Yana Pikman,

    Affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Benjamin H Lee,

    Affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Thomas Mercher,

    Affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Elizabeth McDowell,

    Affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Benjamin L Ebert,

    Affiliations: Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Maricel Gozo,

    Affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Adam Cuker,

    Affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Gerlinde Wernig,

    Affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Sandra Moore,

    Affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Ilene Galinsky,

    Affiliation: Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Daniel J DeAngelo,

    Affiliation: Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Jennifer J Clark,

    Affiliation: Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Stephanie J Lee,

    Affiliation: Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Todd R Golub,

    Affiliations: Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Boston, Massachusetts, United States of America

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  • Martha Wadleigh,

    Affiliation: Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • D. Gary Gilliland,

    Affiliations: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Boston, Massachusetts, United States of America

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  • Ross L Levine mail

    To whom correspondence should be addressed. E-mail: ross_levine@dfci.harvard.edu

    Affiliations: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: July 18, 2006
  • DOI: 10.1371/journal.pmed.0030270

About the Authors

Yana Pikman, Benjamin H Lee, Thomas Mercher, Elizabeth McDowell, Maricel Gozo, Adam Cuker, Gerlinde Wernig, Sandra Moore, D. Gary Gilliland, Ross L Levine
Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Benjamin L Ebert, Ilene Galinsky, Daniel J DeAngelo, Jennifer J Clark, Stephanie J Lee, Todd R Golub, Martha Wadleigh, D. Gary Gilliland, Ross L Levine
Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
Benjamin L Ebert, Todd R Golub
Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
Todd R Golub, D. Gary Gilliland
Howard Hughes Medical Institute, Boston, Massachusetts, United States of America

Corresponding Author

Email: ross_levine@dfci.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

YP, DGG, and RLL designed the study and wrote the manuscript. YP, BHL, TM, BLE, and RLL performed research and analyzed data. BHL and TM contributed to writing the manuscript. EMD, MG, AC, JJC, and MW performed research. SM provided technical assistance. IG, DJD, and JJC organized the collection of samples at Dana-Farber Cancer Institute. GW, SJL, TRG, and MW contributed to study design.