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Research Article

Aberrant Receptor-Mediated Endocytosis of Schistosoma mansoni Glycoproteins on Host Lipoproteins

  • Hein Sprong mail,

    To whom correspondence should be addressed. E-mail: H.Sprong@chem.uu.nl (HS); Thiele@mpi-cbg.de (CT)

    Affiliation: Department of Membrane Enzymology, Bijvoet Center, Utrecht University, Utrecht, Netherlands

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  • Monika Suchanek,

    Affiliation: Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

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  • Suzanne M van Dijk,

    Affiliations: Department of Membrane Enzymology, Bijvoet Center, Utrecht University, Utrecht, Netherlands, Department of Cell Biology, Utrecht University, Utrecht, Netherlands

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  • Alexandra van Remoortere,

    Affiliation: Department of Parasitology, Leiden University Medical Centre, Leiden, Netherlands

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  • Judith Klumperman,

    Affiliation: Department of Cell Biology, Utrecht University, Utrecht, Netherlands

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  • Diana Avram,

    Affiliation: Department of Biochemistry of Lipids, Utrecht University, Utrecht, Netherlands

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  • Joke van der Linden,

    Affiliation: Immunotherapy Laboratory, Department of Immunology, University Medical Center Utrecht, Netherlands

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  • Jeanette H. W Leusen,

    Affiliation: Immunotherapy Laboratory, Department of Immunology, University Medical Center Utrecht, Netherlands

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  • Jaap J van Hellemond,

    Affiliation: Department of Biochemistry and Cell Biology, Institute of Biomembranes, Utrecht University, Utrecht, Netherlands

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  • Christoph Thiele mail

    To whom correspondence should be addressed. E-mail: H.Sprong@chem.uu.nl (HS); Thiele@mpi-cbg.de (CT)

    Affiliation: Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

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  • Published: July 18, 2006
  • DOI: 10.1371/journal.pmed.0030253

About the Authors

Hein Sprong, Suzanne M van Dijk
Department of Membrane Enzymology, Bijvoet Center, Utrecht University, Utrecht, Netherlands
Monika Suchanek, Christoph Thiele
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Suzanne M van Dijk, Judith Klumperman
Department of Cell Biology, Utrecht University, Utrecht, Netherlands
Alexandra van Remoortere
Department of Parasitology, Leiden University Medical Centre, Leiden, Netherlands
Diana Avram
Department of Biochemistry of Lipids, Utrecht University, Utrecht, Netherlands
Joke van der Linden, Jeanette H. W Leusen
Immunotherapy Laboratory, Department of Immunology, University Medical Center Utrecht, Netherlands
Jaap J van Hellemond
Department of Biochemistry and Cell Biology, Institute of Biomembranes, Utrecht University, Utrecht, Netherlands

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

HS, MS, and CT designed the study. HS, MS, SMvD, AvR, and JK analysed the data. HS, SMvD, JK, JJvH, and CT contributed to writing the paper. HS, SMvD, AvR, JK, DA, JvdL, and JJvH collected data or did experiments for the study. SMvD acquired and analysed the electron microscopy data, and contributed to the writing of the results and methods. JK was responsible for design, performance, analysis, and text of the electron microscopy data. JJvH contributed significantly to the design, performance, data interpretation, and writing of all experiments in which living schistosomes or (non)infected hamsters were used (data presented in Figures 3, 5, and 7). These experiments were conducted in the laboratory of JJvH.