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Research Article

Predicting Survival within the Lung Cancer Histopathological Hierarchy Using a Multi-Scale Genomic Model of Development

  • Hongye Liu mail,

    To whom correspondence should be addressed. E-mail: hongye.liu@childrens.harvard.edu

    Affiliations: Children's Hospital Informatics Program, Children's Hospital Boston, Boston, Massachusetts, United States of America, Department of Newborn Medicine, Children's Hospital Boston, Boston, Massachusetts, United States of America

    X
  • Alvin T Kho,

    Affiliations: Children's Hospital Informatics Program, Children's Hospital Boston, Boston, Massachusetts, United States of America, Harvard–Massachusetts Institute of Technology, Division of Health Sciences and Technology, Cambridge, Massachusetts, United States of America

    X
  • Isaac S Kohane,

    Affiliations: Children's Hospital Informatics Program, Children's Hospital Boston, Boston, Massachusetts, United States of America, Harvard–Massachusetts Institute of Technology, Division of Health Sciences and Technology, Cambridge, Massachusetts, United States of America

    X
  • Yao Sun

    Affiliations: Children's Hospital Informatics Program, Children's Hospital Boston, Boston, Massachusetts, United States of America, Department of Newborn Medicine, Children's Hospital Boston, Boston, Massachusetts, United States of America, Harvard–Massachusetts Institute of Technology, Division of Health Sciences and Technology, Cambridge, Massachusetts, United States of America

    X
  • Published: July 04, 2006
  • DOI: 10.1371/journal.pmed.0030232

About the Authors

Hongye Liu, Alvin T Kho, Isaac S Kohane, Yao Sun
Children's Hospital Informatics Program, Children's Hospital Boston, Boston, Massachusetts, United States of America
Hongye Liu, Yao Sun
Department of Newborn Medicine, Children's Hospital Boston, Boston, Massachusetts, United States of America
Alvin T Kho, Isaac S Kohane, Yao Sun
Harvard–Massachusetts Institute of Technology, Division of Health Sciences and Technology, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: hongye.liu@childrens.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ISK originally introduced HL and YS to the idea that human cancer can be examined through the lens of murine development. YS and HL designed the study. HL analyzed the data. ATK and YS provided direction on data analysis. HL, ATK, ISK, and YS contributed to writing the paper.