Advertisement
Research Article

Deployment of Early Diagnosis and Mefloquine- Artesunate Treatment of Falciparum Malaria in Thailand: The Tak Malaria Initiative

  • Verena Ilona Carrara,

    Affiliations: Shoklo Malaria Research Unit, Tak, Thailand, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Departments of Medical Entomology, Tropical Hygiene and Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

    X
  • Supakit Sirilak,

    Affiliation: Public Health Office, Tak, Thailand

    X
  • Janjira Thonglairuam,

    Affiliation: Public Health Office, Tak, Thailand

    X
  • Chaiporn Rojanawatsirivet,

    Affiliation: Ministry of Public Health, Nonthaburi, Thailand

    X
  • Stephane Proux,

    Affiliation: Shoklo Malaria Research Unit, Tak, Thailand

    X
  • Valery Gilbos,

    Affiliation: Shoklo Malaria Research Unit, Tak, Thailand

    X
  • Al Brockman,

    Affiliations: Shoklo Malaria Research Unit, Tak, Thailand, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

    X
  • Elizabeth A Ashley,

    Affiliations: Shoklo Malaria Research Unit, Tak, Thailand, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom

    X
  • Rose McGready,

    Affiliations: Shoklo Malaria Research Unit, Tak, Thailand, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom

    X
  • Srivicha Krudsood,

    Affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

    X
  • Somjai Leemingsawat,

    Affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

    X
  • Sornchai Looareesuwan,

    Affiliation: Departments of Medical Entomology, Tropical Hygiene and Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

    X
  • Pratap Singhasivanon,

    Affiliation: Departments of Medical Entomology, Tropical Hygiene and Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

    X
  • Nicholas White,

    Affiliations: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom

    X
  • François Nosten mail

    To whom correspondence should be addressed. E-mail: SMRU@tropmedres.ac

    Affiliations: Shoklo Malaria Research Unit, Tak, Thailand, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom

    X
  • Published: June 06, 2006
  • DOI: 10.1371/journal.pmed.0030183

About the Authors

Verena Ilona Carrara, Stephane Proux, Valery Gilbos, Al Brockman, Elizabeth A Ashley, Rose McGready, François Nosten
Shoklo Malaria Research Unit, Tak, Thailand
Verena Ilona Carrara, Al Brockman, Elizabeth A Ashley, Rose McGready, Srivicha Krudsood, Somjai Leemingsawat, Nicholas White, François Nosten
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Verena Ilona Carrara, Sornchai Looareesuwan, Pratap Singhasivanon
Departments of Medical Entomology, Tropical Hygiene and Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Supakit Sirilak, Janjira Thonglairuam
Public Health Office, Tak, Thailand
Chaiporn Rojanawatsirivet
Ministry of Public Health, Nonthaburi, Thailand
Elizabeth A Ashley, Rose McGready, Nicholas White, François Nosten
Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom

Corresponding Author

Email: SMRU@tropmedres.ac

Competing Interests

NW is chairman of the World Health Organization malaria treatment guidelines committee and is on the editorial board of PLoS Medicine. The authors have no other conflict of interest to declare.

Author Contributions

S. Sirilak, P. Singhasivanon, N. White, and F. Nosten conceptualized and designed the project. V. I. Carrara coordinated the cross-sectional surveys, interpreted the results of all study components, and drafted the manuscript, with F. Nosten. J. Thonglairuam managed the data entry of the public health data and conducted preliminary results of morbidity and mortality. A. Brockman coordinated and analysed the in vitro studies, E. A. Ashley the in vivo studies, and R. McGready the studies related to pregnant women. S. Proux supervised and controlled the quality of all laboratory results. V. Gilbos developed and supervised the Information Education Communication programme. C. Rojanawatsirivet, S. Krudsood, S. Leemingsawat, and S. Looareesuwan coordinated and analysed part of the entomological data. All authors revised the manuscript for intellectual content.