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Research Article

ApoE Plasma Levels and Risk of Cardiovascular Mortality in Old Age

  • Simon P Mooijaart mail,

    To whom correspondence should be addressed. E-mail: s.p.mooijaart@lumc.nl

    Affiliation: Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands

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  • Jimmy F. P Berbée,

    Affiliations: Department of General Internal Medicine, Endocrinology and Metabolism, Leiden University Medical Center, Leiden, Netherlands, Netherlands Organization for Applied Scientific Research—Quality of Life, Gaubius Laboratory, Leiden, Netherlands

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  • Diana van Heemst,

    Affiliation: Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands

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  • Louis M Havekes,

    Affiliations: Department of General Internal Medicine, Endocrinology and Metabolism, Leiden University Medical Center, Leiden, Netherlands, Netherlands Organization for Applied Scientific Research—Quality of Life, Gaubius Laboratory, Leiden, Netherlands, Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands

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  • Anton J. M de Craen,

    Affiliation: Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands

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  • P. Eline Slagboom,

    Affiliation: Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands

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  • Patrick C. N Rensen,

    Affiliations: Department of General Internal Medicine, Endocrinology and Metabolism, Leiden University Medical Center, Leiden, Netherlands, Netherlands Organization for Applied Scientific Research—Quality of Life, Gaubius Laboratory, Leiden, Netherlands

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  • Rudi G. J Westendorp

    Affiliation: Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands

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  • Published: May 09, 2006
  • DOI: 10.1371/journal.pmed.0030176

About the Authors

Simon P Mooijaart, Diana van Heemst, Anton J. M de Craen, Rudi G. J Westendorp
Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands
Jimmy F. P Berbée, Louis M Havekes, Patrick C. N Rensen
Department of General Internal Medicine, Endocrinology and Metabolism, Leiden University Medical Center, Leiden, Netherlands
Jimmy F. P Berbée, Louis M Havekes, Patrick C. N Rensen
Netherlands Organization for Applied Scientific Research—Quality of Life, Gaubius Laboratory, Leiden, Netherlands
Louis M Havekes
Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands
P. Eline Slagboom
Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands

Corresponding Author

Email: s.p.mooijaart@lumc.nl

Competing Interests

We declare that all authors on the manuscript are co-inventors on a pending patent application entitled “Apolipoprotein E plasma levels for monitoring and reducing the risk of cardiovascular disease,” of which the contents are based on the results described in the present study.

Author Contributions

SPM, JFPB, DvH, LMH, AJMdC, PES, PCNR, and RGJW were involved in design of the study and interpretation of the results. SPM, JFPB, DvH, PCNR, and RGJW wrote the manuscript. SPM and DvH analyzed the data and RGJW supervised. JFPB determined the apoE levels. AJMdC assisted in statistical analyses. LMH and PES assisted in interpretation of the results. PCNR and RGJW obtained funding. RGJW organized patient data collection.