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Research Article

Differential Effects of HOXB4 on Nonhuman Primate Short- and Long-Term Repopulating Cells

  • Xiao-Bing Zhang,

    Affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Brian C Beard,

    Affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Katherine Beebe,

    Affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Barry Storer,

    Affiliations: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

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  • R. Keith Humphries,

    Affiliations: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

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  • Hans-Peter Kiem mail

    To whom correspondence should be addressed. E-mail: hkiem@fhcrc.org

    Affiliations: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Departments of Medicine and Pathology, University of Washington, Seattle, Washington, United States of America

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  • Published: May 02, 2006
  • DOI: 10.1371/journal.pmed.0030173

About the Authors

Xiao-Bing Zhang, Brian C Beard, Katherine Beebe, Barry Storer, Hans-Peter Kiem
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Barry Storer
Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
R. Keith Humphries
Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
R. Keith Humphries
Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Hans-Peter Kiem
Departments of Medicine and Pathology, University of Washington, Seattle, Washington, United States of America

Corresponding Author

Email: hkiem@fhcrc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

XBZ performed the experiments. BCB performed the integration-site studies. KB assisted with the analysis of the experiments. BS performed the statistical analyses. RKH assisted with the design and interpretation of results. HPK designed the experiments and wrote the paper.