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Research Article

Linkage Disequilibrium Mapping of CHEK2: Common Variation and Breast Cancer Risk

  • Kristjana Einarsdóttir,

    Affiliations: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, Population Genetics, Genome Institute of Singapore, Singapore

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  • Keith Humphreys,

    Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

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  • Carine Bonnard,

    Affiliation: Population Genetics, Genome Institute of Singapore, Singapore

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  • Juni Palmgren,

    Affiliations: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, Department of Mathematics, Stockholm University, Stockholm, Sweden

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  • Mark M Iles,

    Affiliation: Genetic Epidemiology Division, Cancer Research UK Clinical Centre, St James's University Hospital, Leeds, United Kingdom

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  • Arvid Sjölander,

    Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

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  • Yuqing Li,

    Affiliation: Population Genetics, Genome Institute of Singapore, Singapore

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  • Kee Seng Chia,

    Affiliation: Center for Molecular Epidemiology, Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore

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  • Edison T Liu,

    Affiliation: Population Genetics, Genome Institute of Singapore, Singapore

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  • Per Hall,

    Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

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  • Jianjun Liu mail,

    To whom correspondence should be addressed. E-mail: liuj3@gis.a-star.edu.sg

    Affiliation: Population Genetics, Genome Institute of Singapore, Singapore

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  • Sara Wedrén

    Affiliations: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, Population Genetics, Genome Institute of Singapore, Singapore, Center for Molecular Epidemiology, Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore

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  • Published: May 09, 2006
  • DOI: 10.1371/journal.pmed.0030168

About the Authors

Kristjana Einarsdóttir, Keith Humphreys, Juni Palmgren, Arvid Sjölander, Per Hall, Sara Wedrén
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Kristjana Einarsdóttir, Carine Bonnard, Yuqing Li, Edison T Liu, Jianjun Liu, Sara Wedrén
Population Genetics, Genome Institute of Singapore, Singapore
Juni Palmgren
Department of Mathematics, Stockholm University, Stockholm, Sweden
Mark M Iles
Genetic Epidemiology Division, Cancer Research UK Clinical Centre, St James's University Hospital, Leeds, United Kingdom
Kee Seng Chia, Sara Wedrén
Center for Molecular Epidemiology, Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore

Corresponding Author

Email: liuj3@gis.a-star.edu.sg

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KE, JL, and SW wrote the article. KE and KH performed the statistical analyses with the assistance of JP, MMI, and AS. CB oversaw the genotyping procedures, and KE assisted with the genotyping. KE and YL selected the polymorphisms. JL and SW coordinated the study. KH, JP, KSC, ETL, PH, JL, and SW contributed to conception and design of the project and critically revised the manuscript. All authors read and approved the final manuscript.