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Research Article

Streptococcal Toxic Shock Syndrome Caused by Streptococcus suis Serotype 2

  • Jiaqi Tang equal contributor mail,

    equal contributor Contributed equally to this work with: Jiaqi Tang, Changjun Wang, Youjun Feng, Weizhong Yang, Huaidong Song, Zhihai Chen, Hongjie Yu

    To whom correspondence should be addressed. E-mail: gaof@im.ac.cn (GFG), E-mail: tjq85@hotmail.com (JT), E-mail: xnwang@21cn.net (XW), E-mail: wangyu@chinacdc.net.cn (YW).

    Affiliation: Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China

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  • Changjun Wang equal contributor,

    equal contributor Contributed equally to this work with: Jiaqi Tang, Changjun Wang, Youjun Feng, Weizhong Yang, Huaidong Song, Zhihai Chen, Hongjie Yu

    Affiliation: Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China

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  • Youjun Feng equal contributor,

    equal contributor Contributed equally to this work with: Jiaqi Tang, Changjun Wang, Youjun Feng, Weizhong Yang, Huaidong Song, Zhihai Chen, Hongjie Yu

    Affiliations: Center for Molecular Immunology and State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, Graduate School, Chinese Academy of Sciences, Beijing, China

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  • Weizhong Yang equal contributor,

    equal contributor Contributed equally to this work with: Jiaqi Tang, Changjun Wang, Youjun Feng, Weizhong Yang, Huaidong Song, Zhihai Chen, Hongjie Yu

    Affiliation: Chinese Center for Disease Control and Prevention (China CDC), Beijing, China

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  • Huaidong Song equal contributor,

    equal contributor Contributed equally to this work with: Jiaqi Tang, Changjun Wang, Youjun Feng, Weizhong Yang, Huaidong Song, Zhihai Chen, Hongjie Yu

    Affiliations: State Key Laboratory of Medical Genomics, Ruijin Hospital Affiliated to Medical School of Shanghai Jiao-Tong University, Shanghai, China, Chinese National Human Genome Center, Shanghai, China

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  • Zhihai Chen equal contributor,

    equal contributor Contributed equally to this work with: Jiaqi Tang, Changjun Wang, Youjun Feng, Weizhong Yang, Huaidong Song, Zhihai Chen, Hongjie Yu

    Affiliation: Beijing Ditan Hospital, Beijing, China

    X
  • Hongjie Yu equal contributor,

    equal contributor Contributed equally to this work with: Jiaqi Tang, Changjun Wang, Youjun Feng, Weizhong Yang, Huaidong Song, Zhihai Chen, Hongjie Yu

    Affiliation: Chinese Center for Disease Control and Prevention (China CDC), Beijing, China

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  • Xiuzhen Pan,

    Affiliation: Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China

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  • Xiaojun Zhou,

    Affiliation: Department of Pathology, Jinling Hospital of Nanjing, Nanjing, China

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  • Huaru Wang,

    Affiliation: Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China

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  • Bo Wu,

    Affiliation: Department of Pathology, Jinling Hospital of Nanjing, Nanjing, China

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  • Haili Wang,

    Affiliation: Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China

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  • Huamei Zhao,

    Affiliation: Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China

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  • Ying Lin,

    Affiliation: School of Biosciences and Bioengineering, South China University of Technology, Guangzhou, China

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  • Jianhua Yue,

    Affiliation: Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China

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  • Zhenqiang Wu,

    Affiliation: School of Biosciences and Bioengineering, South China University of Technology, Guangzhou, China

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  • Xiaowei He,

    Affiliation: School of Biosciences and Bioengineering, South China University of Technology, Guangzhou, China

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  • Feng Gao,

    Affiliation: Center for Molecular Immunology and State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

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  • Abdul Hamid Khan,

    Affiliations: Center for Molecular Immunology and State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, Graduate School, Chinese Academy of Sciences, Beijing, China

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  • Jian Wang,

    Affiliation: Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, China

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  • Guo-Ping Zhao,

    Affiliation: Chinese National Human Genome Center, Shanghai, China

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  • Yu Wang mail,

    To whom correspondence should be addressed. E-mail: gaof@im.ac.cn (GFG), E-mail: tjq85@hotmail.com (JT), E-mail: xnwang@21cn.net (XW), E-mail: wangyu@chinacdc.net.cn (YW).

    Affiliation: Chinese Center for Disease Control and Prevention (China CDC), Beijing, China

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  • Xiaoning Wang mail,

    To whom correspondence should be addressed. E-mail: gaof@im.ac.cn (GFG), E-mail: tjq85@hotmail.com (JT), E-mail: xnwang@21cn.net (XW), E-mail: wangyu@chinacdc.net.cn (YW).

    Affiliation: School of Biosciences and Bioengineering, South China University of Technology, Guangzhou, China

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  • Zhu Chen,

    Affiliations: State Key Laboratory of Medical Genomics, Ruijin Hospital Affiliated to Medical School of Shanghai Jiao-Tong University, Shanghai, China, Chinese National Human Genome Center, Shanghai, China

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  • George F Gao mail

    To whom correspondence should be addressed. E-mail: gaof@im.ac.cn (GFG), E-mail: tjq85@hotmail.com (JT), E-mail: xnwang@21cn.net (XW), E-mail: wangyu@chinacdc.net.cn (YW).

    Affiliation: Center for Molecular Immunology and State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

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  • Published: April 11, 2006
  • DOI: 10.1371/journal.pmed.0030151

About the Authors

Jiaqi Tang, Changjun Wang, Xiuzhen Pan, Huaru Wang, Haili Wang, Huamei Zhao, Jianhua Yue
Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China
Youjun Feng, Feng Gao, Abdul Hamid Khan, George F Gao
Center for Molecular Immunology and State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Weizhong Yang, Hongjie Yu, Yu Wang
Chinese Center for Disease Control and Prevention (China CDC), Beijing, China
Huaidong Song, Zhu Chen
State Key Laboratory of Medical Genomics, Ruijin Hospital Affiliated to Medical School of Shanghai Jiao-Tong University, Shanghai, China
Zhihai Chen
Beijing Ditan Hospital, Beijing, China
Xiaojun Zhou, Bo Wu
Department of Pathology, Jinling Hospital of Nanjing, Nanjing, China
Ying Lin, Zhenqiang Wu, Xiaowei He, Xiaoning Wang
School of Biosciences and Bioengineering, South China University of Technology, Guangzhou, China
Jian Wang
Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, China
Huaidong Song, Guo-Ping Zhao, Zhu Chen
Chinese National Human Genome Center, Shanghai, China
Youjun Feng, Abdul Hamid Khan
Graduate School, Chinese Academy of Sciences, Beijing, China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Jiaqi Tang, Changjun Wang, Weizhong Yang, Zhihai Chen, Hongjie Yu, Xiaojun Zhou, Bo Wu, and Yu Wang did the clinical investigation in the field. Jiaqi Tang, Zhu Chen, Jian Wang, Guo-Ping Zhao, Xiaoning Wang, and George F. Gao designed the study. Changjun Wang, Youjun Feng, Huaidong Song, Xiaojun Zhou, Huaru Wang, Bo Wu, Haili Wang, Huamei Zhao, Ying Lin, and Jianhua Yue performed the experiments. Changjun Wang, Youjun Feng, Xiuzhen Pan, Zhenqiang Wu, Xiaowei He, Feng Gao, and Abdul Hamid Khan analyzed the data. Jiaqi Tang, Youjun Feng, and George F. Gao wrote the paper.