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Research Article

Large-Scale Evidence for the Effect of the COLIA1 Sp1 Polymorphism on Osteoporosis Outcomes: The GENOMOS Study

  • Stuart H Ralston,

    Affiliations: Rheumatic Diseases Unit, University of Edinburgh, Western General Hospital Edinburgh, Edinburgh, United Kingdom, Department of Medicine and Therapeutics, University of Aberdeen Medical School, Aberdeen, United Kingdom

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  • André G Uitterlinden,

    Affiliation: Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands

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  • Maria Luisa Brandi,

    Affiliation: Department of Internal Medicine, University of Florence, Florence, Italy

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  • Susana Balcells,

    Affiliation: Department of Genetics, University of Barcelona, Barcelona, Spain

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  • Bente L Langdahl,

    Affiliation: Department of Endocrinology, Aarhus Sygehus, Aarhus, Denmark

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  • Paul Lips,

    Affiliation: Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, Netherlands

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  • Roman Lorenc,

    Affiliation: Department of Biochemistry and Experimental Medicine, The Children's Memorial Health Institute, Warsaw, Poland

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  • Barbara Obermayer-Pietsch,

    Affiliation: Department of Endocrinology and Nuclear Medicine, University of Graz, Graz, Austria

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  • Serena Scollen,

    Affiliation: Strangeways Research Laboratory, Cambridge University, Cambridge, United Kingdom

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  • Mariona Bustamante,

    Affiliation: Department of Genetics, University of Barcelona, Barcelona, Spain

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  • Lise Bjerre Husted,

    Affiliation: Department of Endocrinology, Aarhus Sygehus, Aarhus, Denmark

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  • Alisoun H Carey,

    Affiliation: Oxagen Limited, Abingdon, United Kingdom

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  • Adolfo Diez-Perez,

    Affiliation: Hospital del Mar-IMIM, Universitat Autònoma de Barcelona, Barcelona, Spain

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  • Alison M Dunning,

    Affiliation: Strangeways Research Laboratory, Cambridge University, Cambridge, United Kingdom

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  • Alberto Falchetti,

    Affiliation: Department of Internal Medicine, University of Florence, Florence, Italy

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  • Elzbieta Karczmarewicz,

    Affiliation: Department of Biochemistry and Experimental Medicine, The Children's Memorial Health Institute, Warsaw, Poland

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  • Marcin Kruk,

    Affiliation: Department of Biochemistry and Experimental Medicine, The Children's Memorial Health Institute, Warsaw, Poland

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  • Johannes P. T. M. van Leeuwen,

    Affiliation: Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands

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  • Joyce B. J. van Meurs,

    Affiliation: Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands

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  • Jon Mangion,

    Affiliation: Oxagen Limited, Abingdon, United Kingdom

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  • Fiona E. A McGuigan,

    Affiliation: Department of Medicine and Therapeutics, University of Aberdeen Medical School, Aberdeen, United Kingdom

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  • Leonardo Mellibovsky,

    Affiliation: Hospital del Mar-IMIM, Universitat Autònoma de Barcelona, Barcelona, Spain

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  • Francesca del Monte,

    Affiliation: Department of Internal Medicine, University of Florence, Florence, Italy

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  • Huibert A. P Pols,

    Affiliation: Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands

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  • Jonathan Reeve,

    Affiliation: Strangeways Research Laboratory, Cambridge University, Cambridge, United Kingdom

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  • David M Reid,

    Affiliation: Department of Medicine and Therapeutics, University of Aberdeen Medical School, Aberdeen, United Kingdom

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  • Wilfried Renner,

    Affiliation: Department of Endocrinology and Nuclear Medicine, University of Graz, Graz, Austria

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  • Fernando Rivadeneira,

    Affiliation: Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands

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  • Natasja M. van Schoor,

    Affiliation: Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, Netherlands

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  • Rachael E Sherlock,

    Affiliation: Oxagen Limited, Abingdon, United Kingdom

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  • John P. A Ioannidis,

    Affiliation: Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine and Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina, Greece

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  • for the GENOMOS investigators
  • Published: February 21, 2006
  • DOI: 10.1371/journal.pmed.0030090

About the Authors

Stuart H Ralston
Rheumatic Diseases Unit, University of Edinburgh, Western General Hospital Edinburgh, Edinburgh, United Kingdom
Stuart H Ralston, Fiona E. A McGuigan, David M Reid
Department of Medicine and Therapeutics, University of Aberdeen Medical School, Aberdeen, United Kingdom
André G Uitterlinden, Johannes P. T. M. van Leeuwen, Joyce B. J. van Meurs, Huibert A. P Pols, Fernando Rivadeneira
Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands
Maria Luisa Brandi, Alberto Falchetti, Francesca del Monte
Department of Internal Medicine, University of Florence, Florence, Italy
Susana Balcells, Mariona Bustamante
Department of Genetics, University of Barcelona, Barcelona, Spain
Bente L Langdahl, Lise Bjerre Husted
Department of Endocrinology, Aarhus Sygehus, Aarhus, Denmark
Paul Lips, Natasja M. van Schoor
Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, Netherlands
Roman Lorenc, Elzbieta Karczmarewicz, Marcin Kruk
Department of Biochemistry and Experimental Medicine, The Children's Memorial Health Institute, Warsaw, Poland
Barbara Obermayer-Pietsch, Wilfried Renner
Department of Endocrinology and Nuclear Medicine, University of Graz, Graz, Austria
Serena Scollen, Alison M Dunning, Jonathan Reeve
Strangeways Research Laboratory, Cambridge University, Cambridge, United Kingdom
Alisoun H Carey, Jon Mangion, Rachael E Sherlock
Oxagen Limited, Abingdon, United Kingdom
Adolfo Diez-Perez, Leonardo Mellibovsky
Hospital del Mar-IMIM, Universitat Autònoma de Barcelona, Barcelona, Spain
John P. A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine and Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina, Greece

Corresponding Author

Email: jioannid@cc.uoi.gr

Competing Interests

SHR, AGU, HAPP, and JPTMvL hold patents on the use of various genetic markers for the diagnosis of osteoporosis, including the COLIA1 Sp1 polymorphism.

Author Contributions

Author contributions and additional contributors are listed at the end of this paper.