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Research Article

Viable Group A Streptococci in Macrophages during Acute Soft Tissue Infection

  • Pontus Thulin,

    Affiliation: Center for Infectious Medicine, Karolinska Institute, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden

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  • Linda Johansson,

    Affiliation: Center for Infectious Medicine, Karolinska Institute, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden

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  • Donald E Low,

    Affiliation: Department of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada

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  • Bing S Gan,

    Affiliations: Department of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada, Department of Surgery, University of Western Ontario, London, Ontario, Canada, Department of Pharmacology/Toxicology, University of Western Ontario, London, Ontario, Canada, Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada

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  • Malak Kotb,

    Affiliations: Department of Surgery, University of Tennessee, Memphis, Tennessee, United States of America, Department of Microbiology, University of Tennessee, Memphis, Tennessee, United States of America, Department of Immunology, University of Tennessee, Memphis, Tennessee, United States of America, Veterans Affairs Medical Center, Research Service, Memphis, Tennessee, United States of America

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  • Allison McGeer,

    Affiliation: Department of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada

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  • Anna Norrby-Teglund mail

    To whom correspondence should be addressed. E-mail: anna.norrby-teglund@medhs.ki.se

    Affiliation: Center for Infectious Medicine, Karolinska Institute, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden

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  • Published: January 17, 2006
  • DOI: 10.1371/journal.pmed.0030053

About the Authors

Pontus Thulin, Linda Johansson, Anna Norrby-Teglund
Center for Infectious Medicine, Karolinska Institute, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
Donald E Low, Bing S Gan, Allison McGeer
Department of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
Bing S Gan
Department of Surgery, University of Western Ontario, London, Ontario, Canada
Bing S Gan
Department of Pharmacology/Toxicology, University of Western Ontario, London, Ontario, Canada
Bing S Gan
Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
Malak Kotb
Department of Surgery, University of Tennessee, Memphis, Tennessee, United States of America
Malak Kotb
Department of Microbiology, University of Tennessee, Memphis, Tennessee, United States of America
Malak Kotb
Department of Immunology, University of Tennessee, Memphis, Tennessee, United States of America
Malak Kotb
Veterans Affairs Medical Center, Research Service, Memphis, Tennessee, United States of America

Corresponding Author

Email: anna.norrby-teglund@medhs.ki.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

PT, DEL, and ANT designed the study. DEL, BSG, and AM enrolled patients. PT and LJ performed the experiments. MK was involved in the design studies with the SpeB wild-type and gene-deletion mutant. PT, LJ, DEL, BSG, MK, and ANT analyzed the data and contributed to writing the paper.