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Research Article

Excess Circulating Angiopoietin-2 May Contribute to Pulmonary Vascular Leak in Sepsis in Humans

  • Samir M Parikh equal contributor,

    equal contributor Contributed equally to this work with: Samir M Parikh, Tadanori Mammoto

    Affiliation: Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Tadanori Mammoto equal contributor,

    equal contributor Contributed equally to this work with: Samir M Parikh, Tadanori Mammoto

    Affiliation: Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Aylit Schultz,

    Affiliation: Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Hai-Tao Yuan,

    Affiliation: Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • David Christiani,

    Affiliation: Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • S. Ananth Karumanchi,

    Affiliation: Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Vikas P Sukhatme mail

    To whom correspondence should be addressed. E-mail: vsukhatm@bidmc.harvard.edu

    Affiliation: Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Published: January 24, 2006
  • DOI: 10.1371/journal.pmed.0030046

About the Authors

Samir M Parikh, Tadanori Mammoto, Aylit Schultz, Hai-Tao Yuan, S. Ananth Karumanchi, Vikas P Sukhatme
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
David Christiani
Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts, United States of America

Corresponding Author

Email: vsukhatm@bidmc.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SMP, TM, DC, SAK, and VPS were responsible for hypothesis generation. SMP and AS were responsible for human data collection and analysis and for institutional review board applications. SMP and TM were responsible for manuscript preparation. SMP, TM, AS, HTY, DC, SAK, and VPS were responsible for final approval of manuscript. TM was responsible for in vitro and animal studies. AS and HTY were responsible for Ang-2 ELISA data acquisition and analysis. SMP, TM, AS, HTY, DC, SAK, and VPS were responsible for critical revision of the manuscript.