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Research Article

Promoter Variation in the DC-SIGN–Encoding Gene CD209 Is Associated with Tuberculosis

  • Luis B Barreiro,

    Affiliations: CNRS FRE2849, Unit of Molecular Prevention and Therapy of Human Diseases, Institut Pasteur, Paris, France, Unité de Génétique Mycobactérienne, Institut Pasteur, Paris, France

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  • Olivier Neyrolles,

    Affiliation: Unité de Génétique Mycobactérienne, Institut Pasteur, Paris, France

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  • Chantal L Babb,

    Affiliation: Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa

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  • Ludovic Tailleux,

    Affiliation: Unité de Génétique Mycobactérienne, Institut Pasteur, Paris, France

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  • Hélène Quach,

    Affiliation: CNRS FRE2849, Unit of Molecular Prevention and Therapy of Human Diseases, Institut Pasteur, Paris, France

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  • Ken McElreavey,

    Affiliation: Reproduction, Fertilité et Populations, Institut Pasteur, Paris, France

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  • Paul D. van Helden,

    Affiliation: Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa

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  • Eileen G Hoal,

    Affiliation: Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa

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  • Brigitte Gicquel,

    Affiliation: Unité de Génétique Mycobactérienne, Institut Pasteur, Paris, France

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  • Lluis Quintana-Murci mail

    To whom correspondence should be addressed. E-mail: quintana@pasteur.fr

    Affiliation: CNRS FRE2849, Unit of Molecular Prevention and Therapy of Human Diseases, Institut Pasteur, Paris, France

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  • Published: January 03, 2006
  • DOI: 10.1371/journal.pmed.0030020

About the Authors

Luis B Barreiro, Hélène Quach, Lluis Quintana-Murci
CNRS FRE2849, Unit of Molecular Prevention and Therapy of Human Diseases, Institut Pasteur, Paris, France
Luis B Barreiro, Olivier Neyrolles, Ludovic Tailleux, Brigitte Gicquel
Unité de Génétique Mycobactérienne, Institut Pasteur, Paris, France
Chantal L Babb, Paul D. van Helden, Eileen G Hoal
Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
Ken McElreavey
Reproduction, Fertilité et Populations, Institut Pasteur, Paris, France

Corresponding Author

Email: quintana@pasteur.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

LBB, ON, BG, and LQ designed the study. LBB, ON, LT, KM, BG, and LQ analyzed the data. LBB, CLB, and HQ performed the sequencing and genotyping analyses. PDH and EGH coordinated the collection, clinical information, and DNA extraction of the cohort samples. LBB, ON, CLB, LT, HQ, KM, PDH, EGH, BG, and LQ contributed to writing the paper.