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Research Article

Interleukin-1 Stimulates β-Cell Necrosis and Release of the Immunological Adjuvant HMGB1

  • Sarah A Steer,

    Affiliation: The Edward A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, Missouri, United States of America

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  • Anna L Scarim,

    Affiliation: The Edward A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, Missouri, United States of America

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  • Kari T Chambers,

    Affiliation: The Edward A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, Missouri, United States of America

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  • John A Corbett mail

    To whom correspondence should be addressed. E-mail: corbettj@slu.edu

    Affiliation: The Edward A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, Missouri, United States of America

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  • Published: December 20, 2005
  • DOI: 10.1371/journal.pmed.0030017

About the Authors

Sarah A Steer, Anna L Scarim, Kari T Chambers, John A Corbett
The Edward A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, Missouri, United States of America

Corresponding Author

Email: corbettj@slu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SAS, ALS, KTC, and JAC designed the study, analyzed the data, and contributed to writing the paper.