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Research Article

EGF Receptor-Targeted Synthetic Double-Stranded RNA Eliminates Glioblastoma, Breast Cancer, and Adenocarcinoma Tumors in Mice

  • Alexei Shir,

    Affiliation: Department of Biological Chemistry, The Hebrew University of Jerusalem, Givat Ram, Jerusalem, Israel

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  • Manfred Ogris,

    Affiliation: Pharmaceutical Biology-Biotechnology, Department of Pharmacy, Ludwig-Maximilians-Universität, Munich, Germany

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  • Ernst Wagner,

    Affiliation: Pharmaceutical Biology-Biotechnology, Department of Pharmacy, Ludwig-Maximilians-Universität, Munich, Germany

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  • Alexander Levitzki mail

    To whom correspondence should be addressed. E-mail: LEVITZKI@vms.huji.ac.il

    Affiliation: Department of Biological Chemistry, The Hebrew University of Jerusalem, Givat Ram, Jerusalem, Israel

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  • Published: December 06, 2005
  • DOI: 10.1371/journal.pmed.0030006

About the Authors

Alexei Shir, Alexander Levitzki
Department of Biological Chemistry, The Hebrew University of Jerusalem, Givat Ram, Jerusalem, Israel
Manfred Ogris, Ernst Wagner
Pharmaceutical Biology-Biotechnology, Department of Pharmacy, Ludwig-Maximilians-Universität, Munich, Germany

Corresponding Author

Email: LEVITZKI@vms.huji.ac.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AS, MO, EW, and AL designed the study. AS and MO performed the experiments. AS and AL analyzed the data. AS, MO, EW, and AL contributed to writing the paper.