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Research Article

DC-SIGN Induction in Alveolar Macrophages Defines Privileged Target Host Cells for Mycobacteria in Patients with Tuberculosis

  • Ludovic Tailleux mail,

    To whom correspondence should be addressed. E-mail: tailleux@pasteur.fr (LT), E-mail: neyrolle@pasteur.fr (ON)

    Affiliation: Institut Pasteur, Unité de Génétique Mycobactérienne, Paris, France

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  • Nhan Pham-Thi equal contributor,

    equal contributor Contributed equally to this work with: Nhan Pham-Thi, Anne Bergeron-Lafaurie

    Affiliation: Hôpital Necker-Enfants-Malades, AP-HP, Service de Pneumologie et d'Allergologie Pédiatrique, Paris, France

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  • Anne Bergeron-Lafaurie equal contributor,

    equal contributor Contributed equally to this work with: Nhan Pham-Thi, Anne Bergeron-Lafaurie

    Affiliation: Hôpital Saint-Louis, AP-HP, Service de Pneumologie, Paris, France

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  • Jean-Louis Herrmann,

    Affiliation: Hôpital Saint-Louis, AP-HP, Service de Microbiologie, Paris, France

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  • Patricia Charles,

    Affiliation: Institut Pasteur, Unité de Génétique Mycobactérienne, Paris, France

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  • Olivier Schwartz,

    Affiliation: Institut Pasteur, Groupe Virus et Immunité, Paris, France

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  • Pierre Scheinmann,

    Affiliation: Hôpital Necker-Enfants-Malades, AP-HP, Service de Pneumologie et d'Allergologie Pédiatrique, Paris, France

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  • Philippe H Lagrange,

    Affiliation: Hôpital Saint-Louis, AP-HP, Service de Microbiologie, Paris, France

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  • Jacques de Blic,

    Affiliation: Hôpital Necker-Enfants-Malades, AP-HP, Service de Pneumologie et d'Allergologie Pédiatrique, Paris, France

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  • Abdellatif Tazi,

    Affiliation: Hôpital Saint-Louis, AP-HP, Service de Pneumologie, Paris, France

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  • Brigitte Gicquel,

    Affiliation: Institut Pasteur, Unité de Génétique Mycobactérienne, Paris, France

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  • Olivier Neyrolles mail

    To whom correspondence should be addressed. E-mail: tailleux@pasteur.fr (LT), E-mail: neyrolle@pasteur.fr (ON)

    Affiliations: Institut Pasteur, Unité de Génétique Mycobactérienne, Paris, France, Centre National de la Recherche Scientifique, URA 2172, Paris, France

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  • Published: November 15, 2005
  • DOI: 10.1371/journal.pmed.0020381

About the Authors

Ludovic Tailleux, Patricia Charles, Brigitte Gicquel, Olivier Neyrolles
Institut Pasteur, Unité de Génétique Mycobactérienne, Paris, France
Nhan Pham-Thi, Pierre Scheinmann, Jacques de Blic
Hôpital Necker-Enfants-Malades, AP-HP, Service de Pneumologie et d'Allergologie Pédiatrique, Paris, France
Anne Bergeron-Lafaurie, Abdellatif Tazi
Hôpital Saint-Louis, AP-HP, Service de Pneumologie, Paris, France
Jean-Louis Herrmann, Philippe H Lagrange
Hôpital Saint-Louis, AP-HP, Service de Microbiologie, Paris, France
Olivier Schwartz
Institut Pasteur, Groupe Virus et Immunité, Paris, France
Olivier Neyrolles
Centre National de la Recherche Scientifique, URA 2172, Paris, France

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

LT and ON designed the study with the help of NPT, ABL, JLH, PS, PHL, JdB, AT, and BG. NPT, ABL, and JLH performed clinical sampling. LT, PC, OS, and ON performed the experiments. LT and ON wrote the paper with the contribution of NPT, ABL, JLH, OS, PS, PHL, JdB, AT, and BG.