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Research Article

Persistent Amyloidosis following Suppression of Aβ Production in a Transgenic Model of Alzheimer Disease

  • Joanna L Jankowsky mail,

    To whom correspondence should be addressed. E-mail: jlj2@caltech.edu (JLJ); E-mail: borchelt@mbi.ufl.edu (DRB)

    Affiliations: Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Division of Biology, California Institute of Technology, Pasadena, California, United States of America

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  • Hilda H Slunt,

    Affiliation: Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    ¤ Current address: Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America

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  • Victoria Gonzales,

    Affiliation: Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Alena V Savonenko,

    Affiliation: Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Jason C Wen,

    Affiliation: Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Nancy A Jenkins,

    Affiliation: Mouse Cancer Genetics Program, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland, United States of America

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  • Neal G Copeland,

    Affiliation: Mouse Cancer Genetics Program, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland, United States of America

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  • Linda H Younkin,

    Affiliation: Mayo Clinic Jacksonville, Jacksonville, Florida, United States of America

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  • Henry A Lester,

    Affiliation: Division of Biology, California Institute of Technology, Pasadena, California, United States of America

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  • Steven G Younkin,

    Affiliation: Mayo Clinic Jacksonville, Jacksonville, Florida, United States of America

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  • David R Borchelt mail

    To whom correspondence should be addressed. E-mail: jlj2@caltech.edu (JLJ); E-mail: borchelt@mbi.ufl.edu (DRB)

    Affiliations: Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    ¤ Current address: Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America

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  • Published: November 15, 2005
  • DOI: 10.1371/journal.pmed.0020355

About the Authors

Joanna L Jankowsky, Hilda H Slunt, Victoria Gonzales, Alena V Savonenko, David R Borchelt
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Joanna L Jankowsky, Henry A Lester
Division of Biology, California Institute of Technology, Pasadena, California, United States of America
Jason C Wen
Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Nancy A Jenkins, Neal G Copeland
Mouse Cancer Genetics Program, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland, United States of America
Linda H Younkin, Steven G Younkin
Mayo Clinic Jacksonville, Jacksonville, Florida, United States of America
David R Borchelt
Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JLJ and DRB designed the study and wrote the manuscript, JLJ, HHS, VG, JCW, LHY, SGY and DRB performed experiments, NAJ and NGC generated transgenic founders, HAL assisted with data interpretation, and AVS performed statistical analyses.